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New insights into the genetic etiology of Alzheimer's disease and related dementias

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dc.contributor.authorBELLENGUEZ, Celine
dc.contributor.authorKUCUKALI, Fahri
dc.contributor.authorJANSEN, Iris E.
dc.contributor.authorKLEINEIDAM, Luca
dc.contributor.authorMORENO-GRAU, Sonia
dc.contributor.authorAMIN, Najaf
dc.contributor.authorNAJ, Adam C.
dc.contributor.authorCAMPOS-MARTIN, Rafael
dc.contributor.authorGRENIER-BOLEY, Benjamin
dc.contributor.authorANDRADE, Victor
dc.contributor.authorHOLMANS, Peter A.
dc.contributor.authorBOLAND, Anne
dc.contributor.authorDAMOTTE, Vincent
dc.contributor.authorVAN DER LEE, Sven J.
dc.contributor.authorCOSTA, Marcos R.
dc.contributor.authorKUULASMAA, Teemu
dc.contributor.authorYANG, Qiong
dc.contributor.authorDE ROJAS, Itziar
dc.contributor.authorBIS, Joshua C.
dc.contributor.authorYAQUB, Amber
dc.contributor.authorPROKIC, Ivana
dc.contributor.authorCHAPUIS, Julien
dc.contributor.authorAHMAD, Shahzad
dc.contributor.authorGIEDRAITIS, Vilmantas
dc.contributor.authorAARSLAND, Dag
dc.contributor.authorGARCIA-GONZALEZ, Pablo
dc.contributor.authorABDELNOUR, Carla
dc.contributor.authorALARCON-MARTIN, Emilio
dc.contributor.authorALCOLEA, Daniel
dc.contributor.authorALEGRET, Montserrat
dc.contributor.authorALVAREZ, Ignacio
dc.contributor.authorALVAREZ, Victoria
dc.contributor.authorARMSTRONG, Nicola J.
dc.contributor.authorTSOLAKI, Anthoula
dc.contributor.authorANTUNEZ, Carmen
dc.contributor.authorAPPOLLONIO, Ildebrando
dc.contributor.authorARCARO, Marina
dc.contributor.authorARCHETTI, Silvana
dc.contributor.authorPASTOR, Alfonso Arias
dc.contributor.authorAROSIO, Beatrice
dc.contributor.authorATHANASIU, Lavinia
dc.contributor.authorBAILLY, Henri
dc.contributor.authorBANAJ, Nerisa
dc.contributor.authorBAQUERO, Miquel
dc.contributor.authorBARRAL, Sandra
dc.contributor.authorBEISER, Alexa
dc.contributor.authorPASTOR, Ana Belen
dc.contributor.authorBELOW, Jennifer E.
dc.contributor.authorBENCHEK, Penelope
dc.contributor.authorBENUSSI, Luisa
dc.contributor.authorBERR, Claudine
dc.contributor.authorBESSE, Celine
dc.contributor.authorBESSI, Valentina
dc.contributor.authorBINETTI, Giuliano
dc.contributor.authorBIZARRO, Alessandra
dc.contributor.authorBLESA, Rafael
dc.contributor.authorBOADA, Merce
dc.contributor.authorBOERWINKLE, Eric
dc.contributor.authorBORRONI, Barbara
dc.contributor.authorBOSCHI, Silvia
dc.contributor.authorBOSSU, Paola
dc.contributor.authorBRATHEN, Geir
dc.contributor.authorBRESSLER, Jan
dc.contributor.authorBRESNER, Catherine
dc.contributor.authorBRODATY, Henry
dc.contributor.authorBROOKES, Keeley J.
dc.contributor.authorBRUSCO, Luis Ignacio
dc.contributor.authorBUIZA-RUEDA, Dolores
dc.contributor.authorBURGER, Katharina
dc.contributor.authorBURHOLT, Vanessa
dc.contributor.authorBUSH, William S.
dc.contributor.authorCALERO, Miguel
dc.contributor.authorCANTWELL, Laura B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorCHUNG, Jaeyoon
dc.contributor.authorCUCCARO, Michael L.
dc.contributor.authorCARRACEDO, Angel
dc.contributor.authorCECCHETTI, Roberta
dc.contributor.authorCERVERA-CARLES, Laura
dc.contributor.authorCHARBONNIER, Camille
dc.contributor.authorCHEN, Hung-Hsin
dc.contributor.authorCHILLOTTI, Caterina
dc.contributor.authorCICCONE, Simona
dc.contributor.authorCLAASSEN, Jurgen A. H. R.
dc.contributor.authorCLARK, Christopher
dc.contributor.authorCONTI, Elisa
dc.contributor.authorCORMA-GOMEZ, Anais
dc.contributor.authorCOSTANTINI, Emanuele
dc.contributor.authorCUSTODERO, Carlo
dc.contributor.authorDAIAN, Delphine
dc.contributor.authorDALMASSO, Maria Carolina
dc.contributor.authorDANIELE, Antonio
dc.contributor.authorDARDIOTIS, Efthimios
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorDE DEYN, Peter Paul
dc.contributor.authorDE PAIVA LOPES, Katia
dc.contributor.authorDE WITTE, Lot D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDECKERT, Jurgen
dc.contributor.authorDEL SER, Teodoro
dc.contributor.authorDENNING, Nicola
dc.contributor.authorDESTEFANO, Anita
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorDIEHL-SCHMID, Janine
dc.contributor.authorDIEZ-FAIREN, Monica
dc.contributor.authorROSSI, Paolo Dionigi
dc.contributor.authorDJUROVIC, Srdjan
dc.contributor.authorDURON, Emmanuelle
dc.contributor.authorDUZEL, Emrah
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorEIRIKSDOTTIR, Gudny
dc.contributor.authorENGELBORGHS, Sebastiaan
dc.contributor.authorESCOTT-PRICE, Valentina
dc.contributor.authorESPINOSA, Ana
dc.contributor.authorEWERS, Michael
dc.contributor.authorFABER, Kelley M.
dc.contributor.authorFABRIZIO, Tagliavini
dc.contributor.authorNIELSEN, Sune Fallgaard
dc.contributor.authorFARDO, David W.
dc.contributor.authorFAROTTI, Lucia
dc.contributor.authorFENOGLIO, Chiara
dc.contributor.authorFERNANDEZ-FUERTES, Marta
dc.contributor.authorFERRARI, Raffaele
dc.contributor.authorFERREIRA, Catarina B.
dc.contributor.authorFERRI, Evelyn
dc.contributor.authorFIN, Bertrand
dc.contributor.authorFISCHER, Peter
dc.contributor.authorFLADBY, Tormod
dc.contributor.authorFLIESSBACH, Klaus
dc.contributor.authorFONGANG, Bernard
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorFORTEA, Juan
dc.contributor.authorFOROUD, Tatiana M.
dc.contributor.authorFOSTINELLI, Silvia
dc.contributor.authorFOX, Nick C.
dc.contributor.authorFRANCO-MACIAS, Emlio
dc.contributor.authorBULLIDO, Maria J.
dc.contributor.authorFRANK-GARCIA, Ana
dc.contributor.authorFROELICH, Lutz
dc.contributor.authorFULTON-HOWARD, Brian
dc.contributor.authorGALIMBERTI, Daniela
dc.contributor.authorGARCIA-ALBERCA, Jose Maria
dc.contributor.authorGARCIA-MADRONA, Sebastian
dc.contributor.authorGARCIA-RIBAS, Guillermo
dc.contributor.authorGHIDONI, Roberta
dc.contributor.authorGIEGLING, Ina
dc.contributor.authorGIORGIO, Giaccone
dc.contributor.authorGOATE, Alison M.
dc.contributor.authorGOLDHARDT, Oliver
dc.contributor.authorGOMEZ-FONSECA, Duber
dc.contributor.authorGONZALEZ-PEREZ, Antonio
dc.contributor.authorGRAFF, Caroline
dc.contributor.authorGRANDE, Giulia
dc.contributor.authorGREEN, Emma
dc.contributor.authorGRIMMER, Timo
dc.contributor.authorGRUNBLATT, Edna
dc.contributor.authorGRUNIN, Michelle
dc.contributor.authorGUDNASON, Vilmundur
dc.contributor.authorGUETTA-BARANES, Tamar
dc.contributor.authorHAAPASALO, Annakaisa
dc.contributor.authorHADJIGEORGIOU, Georgios
dc.contributor.authorHAINES, Jonathan L.
dc.contributor.authorHAMILTON-NELSON, Kara L.
dc.contributor.authorHAMPEL, Harald
dc.contributor.authorHANON, Olivier
dc.contributor.authorHARDY, John
dc.contributor.authorHARTMANN, Annette M.
dc.contributor.authorHAUSNER, Lucrezia
dc.contributor.authorHARWOOD, Janet
dc.contributor.authorHEILMANN-HEIMBACH, Stefanie
dc.contributor.authorHELISALMI, Seppo
dc.contributor.authorHENEKA, Michael T.
dc.contributor.authorHERNANDEZ, Isabel
dc.contributor.authorHERRMANN, Martin J.
dc.contributor.authorHOFFMANN, Per
dc.contributor.authorHOLMES, Clive
dc.contributor.authorHOLSTEGE, Henne
dc.contributor.authorVILAS, Raquel Huerto
dc.contributor.authorHULSMAN, Marc
dc.contributor.authorHUMPHREY, Jack
dc.contributor.authorBIESSELS, Geert Jan
dc.contributor.authorJIAN, Xueqiu
dc.contributor.authorJOHANSSON, Charlotte
dc.contributor.authorJUN, Gyungah R.
dc.contributor.authorKASTUMATA, Yuriko
dc.contributor.authorKAUWE, John
dc.contributor.authorKEHOE, Patrick G.
dc.contributor.authorKILANDER, Lena
dc.contributor.authorSTAHLBOM, Anne Kinhult
dc.contributor.authorKIVIPELTO, Miia
dc.contributor.authorKOIVISTO, Anne
dc.contributor.authorKORNHUBER, Johannes
dc.contributor.authorKOSMIDIS, Mary H.
dc.contributor.authorKUKULL, Walter A.
dc.contributor.authorKUKSA, Pavel P.
dc.contributor.authorKUNKLE, Brian W.
dc.contributor.authorKUZMA, Amanda B.
dc.contributor.authorLAGE, Carmen
dc.contributor.authorLAUKKA, Erika J.
dc.contributor.authorLAUNER, Lenore
dc.contributor.authorLAURIA, Alessandra
dc.contributor.authorLEE, Chien-Yueh
dc.contributor.authorLEHTISALO, Jenni
dc.contributor.authorLERCH, Ondrej
dc.contributor.authorLLEO, Alberto
dc.contributor.authorLONGSTRETH, William Jr
dc.contributor.authorLOPEZ, Oscar
dc.contributor.authorDE MUNAIN, Adolfo Lopez
dc.contributor.authorLOVE, Seth
dc.contributor.authorLOWEMARK, Malin
dc.contributor.authorLUCKCUCK, Lauren
dc.contributor.authorLUNETTA, Kathryn L.
dc.contributor.authorMA, Yiyi
dc.contributor.authorMACIAS, Juan
dc.contributor.authorMACLEOD, Catherine A.
dc.contributor.authorMAIER, Wolfgang
dc.contributor.authorMANGIALASCHE, Francesca
dc.contributor.authorSPALLAZZI, Marco
dc.contributor.authorMARQUIE, Marta
dc.contributor.authorMARSHALL, Rachel
dc.contributor.authorMARTIN, Eden R.
dc.contributor.authorMONTES, Angel Martin
dc.contributor.authorRODRIGUEZ, Carmen Martinez
dc.contributor.authorMASULLO, Carlo
dc.contributor.authorMAYEUX, Richard
dc.contributor.authorMEAD, Simon
dc.contributor.authorMECOCCI, Patrizia
dc.contributor.authorMEDINA, Miguel
dc.contributor.authorMEGGY, Alun
dc.contributor.authorMEHRABIAN, Shima
dc.contributor.authorMENDOZA, Silvia
dc.contributor.authorMENENDEZ-GONZALEZ, Manuel
dc.contributor.authorMIR, Pablo
dc.contributor.authorMOEBUS, Susanne
dc.contributor.authorMOL, Merel
dc.contributor.authorMOLINA-PORCEL, Laura
dc.contributor.authorMONTRREAL, Laura
dc.contributor.authorMORELLI, Laura
dc.contributor.authorMORENO, Fermin
dc.contributor.authorMORGAN, Kevin
dc.contributor.authorMOSLEY, Thomas
dc.contributor.authorNOTHEN, Markus M.
dc.contributor.authorMUCHNIK, Carolina
dc.contributor.authorMUKHERJEE, Shubhabrata
dc.contributor.authorNACMIAS, Benedetta
dc.contributor.authorNGANDU, Tiia
dc.contributor.authorNICOLAS, Gael
dc.contributor.authorNORDESTGAARD, Borge G.
dc.contributor.authorOLASO, Robert
dc.contributor.authorORELLANA, Adelina
dc.contributor.authorORSINI, Michela
dc.contributor.authorORTEGA, Gemma
dc.contributor.authorPADOVANI, Alessandro
dc.contributor.authorPAOLO, Caffarra
dc.contributor.authorPAPENBERG, Goran
dc.contributor.authorPARNETTI, Lucilla
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorPASTOR, Pau
dc.contributor.authorPELOSO, Gina
dc.contributor.authorPEREZ-CORDON, Alba
dc.contributor.authorPEREZ-TUR, Jordi
dc.contributor.authorPERICARD, Pierre
dc.contributor.authorPETERS, Oliver
dc.contributor.authorPIJNENBURG, Yolande A. L.
dc.contributor.authorPINEDA, Juan A.
dc.contributor.authorPINOL-RIPOLL, Gerard
dc.contributor.authorPISANU, Claudia
dc.contributor.authorPOLAK, Thomas
dc.contributor.authorPOPP, Julius
dc.contributor.authorPOSTHUMA, Danielle
dc.contributor.authorPRILLER, Josef
dc.contributor.authorPUERTA, Raquel
dc.contributor.authorQUENEZ, Olivier
dc.contributor.authorQUINTELA, Ines
dc.contributor.authorTHOMASSEN, Jesper Qvist
dc.contributor.authorRABANO, Alberto
dc.contributor.authorRAINERO, Innocenzo
dc.contributor.authorRAJABLI, Farid
dc.contributor.authorRAMAKERS, Inez
dc.contributor.authorREAL, Luis M.
dc.contributor.authorREINDERS, Marcel J. T.
dc.contributor.authorREITZ, Christiane
dc.contributor.authorREYES-DUMEYER, Dolly
dc.contributor.authorRIDGE, Perry
dc.contributor.authorRIEDEL-HELLER, Steffi
dc.contributor.authorRIEDERER, Peter
dc.contributor.authorROBERTO, Natalia
dc.contributor.authorRODRIGUEZ-RODRIGUEZ, Eloy
dc.contributor.authorRONGVE, Arvid
dc.contributor.authorALLENDE, Irene Rosas
dc.contributor.authorROSENDE-ROCA, Maitee
dc.contributor.authorROYO, Jose Luis
dc.contributor.authorRUBINO, Elisa
dc.contributor.authorRUJESCU, Dan
dc.contributor.authorSAEZ, Maria Eugenia
dc.contributor.authorSAKKA, Paraskevi
dc.contributor.authorSALTVEDT, Ingvild
dc.contributor.authorSANABRIA, Angela
dc.contributor.authorSANCHEZ-ARJONA, Maria Bernal
dc.contributor.authorSANCHEZ-GARCIA, Florentino
dc.contributor.authorJUAN, Pascual Sanchez
dc.contributor.authorSANCHEZ-VALLE, Raquel
dc.contributor.authorSANDO, Sigrid B.
dc.contributor.authorSARNOWSKI, Chloe
dc.contributor.authorSATIZABAL, Claudia L.
dc.contributor.authorSCAMOSCI, Michela
dc.contributor.authorSCARMEAS, Nikolaos
dc.contributor.authorSCARPINI, Elio
dc.contributor.authorSCHELTENS, Philip
dc.contributor.authorSCHERBAUM, Norbert
dc.contributor.authorSCHERER, Martin
dc.contributor.authorSCHMID, Matthias
dc.contributor.authorSCHNEIDER, Anja
dc.contributor.authorSCHOTT, Jonathan M.
dc.contributor.authorSELBAEK, Geir
dc.contributor.authorSERIPA, Davide
dc.contributor.authorSERRANO, Manuel
dc.contributor.authorSHA, Jin
dc.contributor.authorSHADRIN, Alexey A.
dc.contributor.authorSKROBOT, Olivia
dc.contributor.authorSLIFER, Susan
dc.contributor.authorSNIJDERS, Gijsje J. L.
dc.contributor.authorSOININEN, Hilkka
dc.contributor.authorSOLFRIZZI, Vincenzo
dc.contributor.authorSOLOMON, Alina
dc.contributor.authorSONG, Yeunjoo
dc.contributor.authorSORBI, Sandro
dc.contributor.authorSOTOLONGO-GRAU, Oscar
dc.contributor.authorSPALLETTA, Gianfranco
dc.contributor.authorSPOTTKE, Annika
dc.contributor.authorSQUASSINA, Alessio
dc.contributor.authorSTORDAL, Eystein
dc.contributor.authorTARTAN, Juan Pablo
dc.contributor.authorTARRAGA, Lluis
dc.contributor.authorTESI, Niccolo
dc.contributor.authorTHALAMUTHU, Anbupalam
dc.contributor.authorTHOMAS, Tegos
dc.contributor.authorTOSTO, Giuseppe
dc.contributor.authorTRAYKOV, Latchezar
dc.contributor.authorTREMOLIZZO, Lucio
dc.contributor.authorTYBJAERG-HANSEN, Anne
dc.contributor.authorUITTERLINDEN, Andre
dc.contributor.authorULLGREN, Abbe
dc.contributor.authorULSTEIN, Ingun
dc.contributor.authorVALERO, Sergi
dc.contributor.authorVALLADARES, Otto
dc.contributor.authorBROECKHOVEN, Christine Van
dc.contributor.authorVANCE, Jeffery
dc.contributor.authorVARDARAJAN, Badri N.
dc.contributor.authorVAN DER LUGT, Aad
dc.contributor.authorDONGEN, Jasper Van
dc.contributor.authorVAN ROOIJ, Jeroen
dc.contributor.authorVAN SWIETEN, John
dc.contributor.authorVANDENBERGHE, Rik
dc.contributor.authorVERHEY, Frans
dc.contributor.authorVIDAL, Jean-Sebastien
dc.contributor.authorVOGELGSANG, Jonathan
dc.contributor.authorVYHNALEK, Martin
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWAGNER, Michael
dc.contributor.authorWALLON, David
dc.contributor.authorWANG, Li-San
dc.contributor.authorWANG, Ruiqi
dc.contributor.authorWEINHOLD, Leonie
dc.contributor.authorWILTFANG, Jens
dc.contributor.authorWINDLE, Gill
dc.contributor.authorWOODS, Bob
dc.contributor.authorYANNAKOULIA, Mary
dc.contributor.authorZARE, Habil
dc.contributor.authorZHAO, Yi
dc.contributor.authorZHANG, Xiaoling
dc.contributor.authorZHU, Congcong
dc.contributor.authorZULAICA, Miren
dc.contributor.authorFARRER, Lindsay A.
dc.contributor.authorPSATY, Bruce M.
dc.contributor.authorGHANBARI, Mohsen
dc.contributor.authorRAJ, Towfique
dc.contributor.authorSACHDEV, Perminder
dc.contributor.authorMATHER, Karen
dc.contributor.authorJESSEN, Frank
dc.contributor.authorIKRAM, M. Arfan
dc.contributor.authorDE MENDONCA, Alexandre
dc.contributor.authorHORT, Jakub
dc.contributor.authorTSOLAKI, Magda
dc.contributor.authorPERICAK-VANCE, Margaret A.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorWILLIAMS, Julie
dc.contributor.authorFRIKKE-SCHMIDT, Ruth
dc.contributor.authorCLARIMON, Jordi
dc.contributor.authorDELEUZE, Jean-Francois
dc.contributor.authorROSSI, Giacomina
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorANDREASSEN, Ole A.
dc.contributor.authorINGELSSON, Martin
dc.contributor.authorHILTUNEN, Mikko
dc.contributor.authorSLEEGERS, Kristel
dc.contributor.authorSCHELLENBERG, Gerard D.
dc.contributor.authorVAN DUIJN, Cornelia M.
dc.contributor.authorSIMS, Rebecca
dc.contributor.authorVAN DER FLIER, Wiesje M.
dc.contributor.authorRUIZ, Agustin
dc.contributor.authorRAMIREZ, Alfredo
dc.contributor.authorLAMBERT, Jean-Charles
dc.date.accessioned2022-05-16T09:23:55Z
dc.date.available2022-05-16T09:23:55Z
dc.date.issued2022-04-04
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140064
dc.description.abstractEnCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enNew insights into the genetic etiology of Alzheimer's disease and related dementias
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-022-01024-zen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35379992en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page412-436en_US
bordeaux.volume54en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDInstitute Pasteur De Lilleen_US
hal.identifierhal-03668928
hal.version1
hal.date.transferred2022-05-16T09:24:26Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Genetics&rft.date=2022-04-04&rft.volume=54&rft.issue=4&rft.spage=412-436&rft.epage=412-436&rft.eissn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.issn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.au=BELLENGUEZ,%20Celine&KUCUKALI,%20Fahri&JANSEN,%20Iris%20E.&KLEINEIDAM,%20Luca&MORENO-GRAU,%20Sonia&rft.genre=article


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