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Is COVID-19 infection more severe in kidney transplant recipients?

dc.rights.licenseopenen_US
dc.contributor.authorCAILLARD, S.
dc.contributor.authorCHAVAROT, N.
dc.contributor.authorFRANCOIS, H.
dc.contributor.authorMATIGNON, M.
dc.contributor.authorGREZE, C.
dc.contributor.authorKAMAR, N.
dc.contributor.authorGATAULT, P.
dc.contributor.authorTHAUNAT, O.
dc.contributor.authorLEGRIS, T.
dc.contributor.authorFRIMAT, L.
dc.contributor.authorWESTEEL, P.F.
dc.contributor.authorGOUTAUDIER, V.
dc.contributor.authorJDIDOU, M.
dc.contributor.authorSNANOUDJ, R.
dc.contributor.authorCOLOSIO, C.
dc.contributor.authorSICARD, A.
dc.contributor.authorBERTRAND, D.
dc.contributor.authorMOUSSON, C.
dc.contributor.authorBAMOULID, J.
dc.contributor.authorMASSET, C.
dc.contributor.authorTHIERRY, A.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.contributor.authorCHEMOUNY, J.M.
dc.contributor.authorDUVEAU, A.
dc.contributor.authorMOAL, V.
dc.contributor.authorBLANCHO, G.
dc.contributor.authorGRIMBERT, P.
dc.contributor.authorDURRBACH, A.
dc.contributor.authorMOULIN, B.
dc.contributor.authorANGLICHEAU, D.
dc.contributor.authorRUCH, Y.
dc.contributor.authorKAEUFFER, C.
dc.contributor.authorBENOTMANE, I.
dc.contributor.authorSOLIS, M.
dc.contributor.authorLEMEUR, Y.
dc.contributor.authorHAZZAN, M.
dc.contributor.authorDANION, F.
dc.contributor.authorTHE FRENCH SOT COVID, Registry
dc.date.accessioned2022-05-09T10:50:07Z
dc.date.available2022-05-09T10:50:07Z
dc.date.issued2021-03
dc.identifier.issn1600-6143en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140004
dc.description.abstractEnThere are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients and nontransplant patients. We enrolled two groups of patients hospitalized for COVID-19, that is, kidney transplant recipients (KTR) from the French Registry of Solid Organ Transplant (n = 306) and a single-center cohort of nontransplant patients (n = 795). An analysis was performed among subgroups matched for age and risk factors for severe COVID-19 or mortality. Severe COVID-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death. Transplant recipients were younger and had more comorbidities compared to nontransplant patients. They presented with higher creatinine levels and developed more episodes of acute kidney injury. After matching, the 30-day cumulative incidence of severe COVID-19 did not differ between KTR and nontransplant patients; however, 30-day COVID-19-related mortality was significantly higher in KTR (17.9% vs 11.4%, respectively, p = .038). Age >60 years, cardiovascular disease, dyspnea, fever, lymphopenia, and C-reactive protein (CRP) were associated with severe COVID-19 in univariate analysis, whereas transplant status and serum creatinine levels were not. Age >60 years, hypertension, cardiovascular disease, diabetes, CRP >60 mg/L, lymphopenia, kidney transplant status (HR = 1.55), and creatinine level >115 µmol/L (HR = 2.32) were associated with COVID-19-related mortality in univariate analysis. In multivariable analysis, cardiovascular disease, dyspnea, and fever were associated with severe disease, whereas age >60 years, cardiovascular disease, dyspnea, fever, and creatinine level>115 µmol/L retained their independent associations with mortality. KTR had a higher COVID-19-related mortality compared to nontransplant hospitalized patients.
dc.language.isoENen_US
dc.subject.enCardiovascular disease
dc.subject.enClinical research / practice
dc.subject.enGlomerular filtration rate (GFR)
dc.subject.enImmunosuppressive regimens
dc.subject.enInfection and infectious agents - viral
dc.subject.enInfectious disease
dc.subject.enKidney failure / injury
dc.subject.enKidney transplantation / nephrology
dc.title.enIs COVID-19 infection more severe in kidney transplant recipients?
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/ajt.16424en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed33259686en_US
bordeaux.journalAmerican Journal of Transplantationen_US
bordeaux.page1295-1303en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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