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Identifying a novel bile salt hydrolase from the keystone gut bacterium christensenella minuta
| dc.rights.license | open | en_US |
| dc.contributor.author | DEJEAN, G. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | TUDELA, Heloise | |
| dc.contributor.author | BRUNO, L. | |
| dc.contributor.author | KISSI, D. | |
| dc.contributor.author | RAWADI, G. | |
| dc.contributor.author | CLAUS, S.P. | |
| dc.date.accessioned | 2022-05-03T11:24:24Z | |
| dc.date.available | 2022-05-03T11:24:24Z | |
| dc.date.issued | 2021-06-09 | |
| dc.identifier.issn | 2076-2607 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139968 | |
| dc.description.abstractEn | Christensenella minuta are human gut dwelling bacteria that have been proposed as key members of the gut microbiome, regulating energy balance and adiposity of their host. We formerly identified that a novel strain of C. minuta (strain DSM33407) boosted microbiota diversity and stimulated deconjugation of the primary bile acid taurocholic acid in human samples. However, there is no description of a bile salt hydrolase (BSH) protein carried in the genome of C. minuta. Here, we identified and cloned a protein from C. minuta’s genome that carries a potent BSH activity, which preferentially deconjugates glycine-conjugated bile acids. We then retrieved 14,319 putative BSH sequences from the NCBI database and filtered them using the UHGP database to collect a total of 6701 sequences that were used to build the most comprehensive phylogenetic tree of BSH-related enzymes identified in the human microbiome so far. This phylogenetic tree revealed that C. minuta’s BSH amino acid sequence clusters away from others with a threshold of 70% identity. This is therefore the first description of C. minuta’s BSH protein, which may be involved in its unique role within the human gut microbial ecosystem. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Bile acids | |
| dc.subject.en | Bile salt hydrolase | |
| dc.subject.en | Gut microbiome | |
| dc.title.en | Identifying a novel bile salt hydrolase from the keystone gut bacterium christensenella minuta | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/microorganisms9061252 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 34207623 | en_US |
| bordeaux.journal | Microorganisms | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03657835 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-05-03T11:24:27Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microorganisms&rft.date=2021-06-09&rft.volume=9&rft.issue=6&rft.eissn=2076-2607&rft.issn=2076-2607&rft.au=DEJEAN,%20G.&TUDELA,%20Heloise&BRUNO,%20L.&KISSI,%20D.&RAWADI,%20G.&rft.genre=article |
