Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | GUERVILLE, Florent | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BOURDEL-MARCHASSON, Isabelle | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | DÉCHANET-MERVILLE, Julie | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | PELLEGRIN, Isabelle | |
| dc.contributor.author | SOUBEYRAN, Pierre | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | APPAY, Victor | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | LEMOINE, Maël | |
| dc.date.accessioned | 2022-04-21T13:33:12Z | |
| dc.date.available | 2022-04-21T13:33:12Z | |
| dc.date.issued | 2022-03-23 | |
| dc.identifier.issn | 2072-6694 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139886 | |
| dc.description.abstractEn | Aging is associated with chronic low-grade inflammation, cancer incidence and mortality. As inflammation contributes to cancer initiation and progression, one could hypothesize that age-associated chronic low-grade inflammation contributes to the increase in cancer incidence and/or mortality observed during aging. Here, we review the evidence supporting this hypothesis: (1) epidemiological associations between biomarkers of systemic inflammation and cancer incidence and mortality in older people, (2) therapeutic clues suggesting that targeting inflammation could reduce cancer incidence and mortality and (3) experimental evidence from animal models highlighting inflammation as a link between various mechanisms of aging and cancer initiation and progression. Despite a large body of literature linking aging, inflammation and cancer, convincing evidence for the clear implication of specific inflammatory pathways explaining cancer incidence or mortality during aging is still lacking. Further dedicated research is needed to fill these gaps in evidence and pave the way for the development of applications in clinical care. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | aging | |
| dc.subject.en | older persons | |
| dc.subject.en | cancer | |
| dc.subject.en | inflammation | |
| dc.subject.en | cell senescence | |
| dc.subject.en | biomarkers | |
| dc.title.en | Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review. | |
| dc.title.alternative | Cancers (Basel) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/cancers14071622 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 35406394 | en_US |
| bordeaux.journal | Cancers | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03648454 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-04-21T13:33:15Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2022-03-23&rft.volume=14&rft.issue=7&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=GUERVILLE,%20Florent&BOURDEL-MARCHASSON,%20Isabelle&D%C3%89CHANET-MERVILLE,%20Julie&PELLEGRIN,%20Isabelle&SOUBEYRAN,%20Pierre&rft.genre=article |
