Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry
| dc.rights.license | open | en_US |
| dc.contributor.author | PAZDERNIK, Michal | |
| dc.contributor.author | IUNG, Bernard | |
| dc.contributor.author | MUTLU, Bulent | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ALLA, Francois | |
| dc.contributor.author | RIEZEBOS, Robert | |
| dc.contributor.author | KONG, William | |
| dc.contributor.author | CARMO PEREIRA NUNES, Maria | |
| dc.contributor.author | PIERARD, Luc | |
| dc.contributor.author | SRDANOVIC, Ilija | |
| dc.contributor.author | YAMADA, Hirotsugu | |
| dc.contributor.author | DE MARTINO, Andrea | |
| dc.contributor.author | MIGLIORANZA, Marcelo Haertel | |
| dc.contributor.author | MAGNE, Julien | |
| dc.contributor.author | PIPER, Cornelia | |
| dc.contributor.author | LAROCHE, Cecile | |
| dc.contributor.author | MAGGIONI, Aldo P. | |
| dc.contributor.author | LANCELLOTTI, Patrizio | |
| dc.contributor.author | HABIB, Gilbert | |
| dc.contributor.author | SELTON-SUTY, Christine | |
| dc.contributor.author | GROUP, Euro-Endo Investigators | |
| dc.date.accessioned | 2022-04-20T09:32:04Z | |
| dc.date.available | 2022-04-20T09:32:04Z | |
| dc.date.issued | 2022-03-15 | |
| dc.identifier.issn | 1439-0973 (Electronic) 0300-8126 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139872 | |
| dc.description.abstractEn | Purpose: High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods: Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results: As compared to < 80 yo patients, ≥ 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43–3.66]). By propensity analysis, 304 ≥ 80 yo were matched to 608 < 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80 yo. Overall mortality remained higher in ≥ 80 yo (in-hospital: HR 1.50[1.06–2.13], p = 0.0210; 1-yr: HR 1.58[1.21–2.05], p = 0.0006), but was not different from that of < 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion: Although mortality rates are consistently higher in ≥ 80 yo patients than in < 80 yo patients in the general population, mortality of surgery in ≥ 80 yo is similar to < 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80 yo patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Infective endocarditis | |
| dc.subject.en | Elderly | |
| dc.subject.en | Prognosis | |
| dc.subject.en | Surgery | |
| dc.subject.en | Propensity analysis | |
| dc.title.en | Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s15010-022-01792-0 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35290614 | en_US |
| bordeaux.journal | Infection | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Abbott Vascular | en_US |
| bordeaux.identifier.funderID | AstraZeneca | en_US |
| bordeaux.identifier.funderID | Bayer | en_US |
| bordeaux.identifier.funderID | Boehringer Ingelheim | en_US |
| bordeaux.identifier.funderID | Bristol-Myers Squibb | en_US |
| bordeaux.identifier.funderID | Pfizer | en_US |
| bordeaux.identifier.funderID | Daiichi Sankyo Europe | en_US |
| bordeaux.identifier.funderID | Eli Lilly and Company | en_US |
| bordeaux.identifier.funderID | Gedeon Richter | en_US |
| bordeaux.identifier.funderID | Novartis Pharma | en_US |
| bordeaux.identifier.funderID | ResMed | en_US |
| bordeaux.identifier.funderID | Sanofi | en_US |
| bordeaux.identifier.funderID | Servier | en_US |
| bordeaux.identifier.funderID | Vifor Pharma | en_US |
| hal.identifier | hal-03647089 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-04-20T09:32:07Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Infection&rft.date=2022-03-15&rft.eissn=1439-0973%20(Electronic)%200300-8126%20(Linking)&rft.issn=1439-0973%20(Electronic)%200300-8126%20(Linking)&rft.au=PAZDERNIK,%20Michal&IUNG,%20Bernard&MUTLU,%20Bulent&ALLA,%20Francois&RIEZEBOS,%20Robert&rft.genre=article |
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