An interdisciplinary approach to investigate the impact of cobalt in a human keratinocyte cell line
| hal.structure.identifier | Laboratoire de Spéciation des Radionucléides et des Molécules [LSRM] | |
| dc.contributor.author | BRESSON, C. | |
| hal.structure.identifier | Laboratoire de Spéciation des Radionucléides et des Molécules [LSRM] | |
| dc.contributor.author | LAMOUROUX, C. | |
| hal.structure.identifier | Laboratoire de Spéciation des Radionucléides et des Molécules [LSRM] | |
| dc.contributor.author | SANDRE, C. | |
| hal.structure.identifier | Laboratoire de Réactivité des Surfaces et des Interfaces [LRSI] | |
| dc.contributor.author | TABARANT, M. | |
| dc.contributor.author | GAULT, N. | |
| dc.contributor.author | PONCY, J.L. | |
| dc.contributor.author | LEFAIX, J.L. | |
| hal.structure.identifier | Service de Chimie des Procédés de Séparation [SCPS] | |
| dc.contributor.author | DEN AUWER, C. | |
| hal.structure.identifier | Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement [LAMBE] | |
| dc.contributor.author | SPEZIA, R. | |
| hal.structure.identifier | Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement [LAMBE] | |
| dc.contributor.author | GAIGEOT, M.-P. | |
| hal.structure.identifier | Commission des méthodes d'analyse du CEA [CETAMA] | |
| dc.contributor.author | ANSOBORLO, E. | |
| hal.structure.identifier | Laboratoire de Chimie Analytique Bio-Inorganique et Environnement [LCABIE] | |
| dc.contributor.author | MOUNICOU, Sandra | |
| hal.structure.identifier | Chimie Nucléaire Analytique et Bio-environnementale [CNAB] | |
| dc.contributor.author | FRAYSSE, A. | |
| hal.structure.identifier | Chimie Nucléaire Analytique et Bio-environnementale [CNAB] | |
| dc.contributor.author | DEVÈS, Guillaume | |
| hal.structure.identifier | Chimie Nucléaire Analytique et Bio-environnementale [CNAB] | |
| dc.contributor.author | BACQUART, T. | |
| hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
| dc.contributor.author | SEZNEC, H. | |
| hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
| dc.contributor.author | POUTHIER, T. | |
| hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
| dc.contributor.author | MORETTO, P. | |
| hal.structure.identifier | Chimie Nucléaire Analytique et Bio-environnementale [CNAB] | |
| dc.contributor.author | ORTEGA, R. | |
| hal.structure.identifier | Laboratoire de Chimie Analytique Bio-Inorganique et Environnement [LCABIE] | |
| dc.contributor.author | LOBINSKI, Ryszard | |
| hal.structure.identifier | Laboratoire de Spéciation des Radionucléides et des Molécules [LSRM] | |
| dc.contributor.author | MOULIN, C. | |
| dc.date.issued | 2006-11-01 | |
| dc.identifier.issn | 0300-9084 | |
| dc.description.abstractEn | Since in nuclear power plants, risks of skin contact contamination by radiocobalt are significant, we focused on the impact of cobalt on a human cutaneous cell line, i.e. HaCaT keratinocytes. The present paper reports an interdisciplinary approach aimed at clarifying the biochemical mechanisms of metabolism and toxicity of cobalt in HaCaT cells. Firstly, a brief overview of the used instrumental techniques is reported. The following parts present description and discussion of results concerning: (i) toxicological studies concerning cobalt impact towards HaCaT cells (ii) structural and speciation fundamental studies of cobalt-bioligand systems, through X-ray absorption spectroscopy (XAS), ab initio and thermodynamic modelling (iii) preliminary results regarding intracellular cobalt speciation in HaCaT cells using size exclusion chromatrography/inductively coupled plasma-atomic emission spectroscopy (SEC/ICP-AES) and direct in situ analysis by ion beam micropobe analytical techniques. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.subject.en | Ion beam analysis | |
| dc.subject.en | SEC–ICP–AES/UV–Vis | |
| dc.subject.en | Biochemical speciation | |
| dc.subject.en | HaCaT | |
| dc.subject.en | Toxicological studies | |
| dc.subject.en | Cobalt | |
| dc.subject.en | Structural studies (XAS) and ab initio and thermodynamic modelling | |
| dc.title.en | An interdisciplinary approach to investigate the impact of cobalt in a human keratinocyte cell line | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.biochi.2006.09.003 | |
| dc.subject.hal | Physique [physics]/Physique [physics]/Biophysique [physics.bio-ph] | |
| dc.subject.hal | Physique [physics]/Physique [physics]/Chimie-Physique [physics.chem-ph] | |
| bordeaux.journal | Biochimie | |
| bordeaux.page | 1619-1629 | |
| bordeaux.volume | 88 | |
| bordeaux.issue | 11 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | in2p3-00129377 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//in2p3-00129377v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimie&rft.date=2006-11-01&rft.volume=88&rft.issue=11&rft.spage=1619-1629&rft.epage=1619-1629&rft.eissn=0300-9084&rft.issn=0300-9084&rft.au=BRESSON,%20C.&LAMOUROUX,%20C.&SANDRE,%20C.&TABARANT,%20M.&GAULT,%20N.&rft.genre=article |
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