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Copper pathology in vulnerable brain regions in Parkinson's disease.

hal.structure.identifierNeuroscience Research Australia [NeuRA]
hal.structure.identifierSchool of Medical Sciences, Faculty of Medicine
dc.contributor.authorDAVIES, Katherine
hal.structure.identifierINSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale
dc.contributor.authorBOHIC, Sylvain
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorCARMONA, Asunción
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorORTEGA, Richard
hal.structure.identifierNeuroscience Research Australia [NeuRA]
dc.contributor.authorCOTTAM, Veronica
hal.structure.identifierElemental Bio-imaging Facility
hal.structure.identifierThe Florey Institute of Neuroscience and Mental Health
dc.contributor.authorHARE, Dominic
hal.structure.identifierFaculty of Medicine
dc.contributor.authorFINBERG, John
hal.structure.identifierNeuroscience Research Australia [NeuRA]
hal.structure.identifierSchool of Medical Sciences, Faculty of Medicine
dc.contributor.authorREYES, Stefanie
hal.structure.identifierNeuroscience Research Australia [NeuRA]
hal.structure.identifierSchool of Medical Sciences, Faculty of Medicine
dc.contributor.authorHALLIDAY, Glenda
hal.structure.identifierCentre for Cellular and Molecular Biology
dc.contributor.authorMERCER, Julian
hal.structure.identifierNeuroscience Research Australia [NeuRA]
hal.structure.identifierSchool of Medical Sciences, Faculty of Medicine
hal.structure.identifierDiscipline of Biomedical Sciences
dc.contributor.authorDOUBLE, Kay
dc.date.issued2014-04
dc.description.abstractEnSynchrotron-based x-ray fluorescence microscopy, immunofluorescence, and Western blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the vulnerable substantia nigra (SN) and locus coeruleus (LC) and in nondegenerating brain regions in cases of Parkinson's disease (PD) and appropriate healthy and disease controls. In PD and incidental Lewy body disease, levels of Cu and Cu transporter protein 1, were significantly reduced in surviving neurons in the SN and LC. Specific activity of the cuproprotein superoxide dismutase 1 was unchanged in the SN in PD but was enhanced in the parkinsonian anterior cingulate cortex, a region with α-synuclein pathology, normal Cu, and limited cell loss. These data suggest that regions affected by α-synuclein pathology may display enhanced vulnerability and cell loss if Cu-dependent protective mechanisms are compromised. Additional investigation of copper pathology in PD may identify novel targets for the development of protective therapies for this disorder.
dc.language.isoen
dc.title.enCopper pathology in vulnerable brain regions in Parkinson's disease.
dc.title.enCopper pathology in PD
dc.typeArticle de revue
dc.identifier.doi10.1016/j.neurobiolaging.2013.09.034
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
bordeaux.journalNeurobiol Aging
bordeaux.page858-66
bordeaux.volume35
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierinserm-00968923
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-00968923v1
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