Copper pathology in vulnerable brain regions in Parkinson's disease.
hal.structure.identifier | Neuroscience Research Australia [NeuRA] | |
hal.structure.identifier | School of Medical Sciences, Faculty of Medicine | |
dc.contributor.author | DAVIES, Katherine | |
hal.structure.identifier | INSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale | |
dc.contributor.author | BOHIC, Sylvain | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | CARMONA, Asunción | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | ORTEGA, Richard | |
hal.structure.identifier | Neuroscience Research Australia [NeuRA] | |
dc.contributor.author | COTTAM, Veronica | |
hal.structure.identifier | Elemental Bio-imaging Facility | |
hal.structure.identifier | The Florey Institute of Neuroscience and Mental Health | |
dc.contributor.author | HARE, Dominic | |
hal.structure.identifier | Faculty of Medicine | |
dc.contributor.author | FINBERG, John | |
hal.structure.identifier | Neuroscience Research Australia [NeuRA] | |
hal.structure.identifier | School of Medical Sciences, Faculty of Medicine | |
dc.contributor.author | REYES, Stefanie | |
hal.structure.identifier | Neuroscience Research Australia [NeuRA] | |
hal.structure.identifier | School of Medical Sciences, Faculty of Medicine | |
dc.contributor.author | HALLIDAY, Glenda | |
hal.structure.identifier | Centre for Cellular and Molecular Biology | |
dc.contributor.author | MERCER, Julian | |
hal.structure.identifier | Neuroscience Research Australia [NeuRA] | |
hal.structure.identifier | School of Medical Sciences, Faculty of Medicine | |
hal.structure.identifier | Discipline of Biomedical Sciences | |
dc.contributor.author | DOUBLE, Kay | |
dc.date.issued | 2014-04 | |
dc.description.abstractEn | Synchrotron-based x-ray fluorescence microscopy, immunofluorescence, and Western blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the vulnerable substantia nigra (SN) and locus coeruleus (LC) and in nondegenerating brain regions in cases of Parkinson's disease (PD) and appropriate healthy and disease controls. In PD and incidental Lewy body disease, levels of Cu and Cu transporter protein 1, were significantly reduced in surviving neurons in the SN and LC. Specific activity of the cuproprotein superoxide dismutase 1 was unchanged in the SN in PD but was enhanced in the parkinsonian anterior cingulate cortex, a region with α-synuclein pathology, normal Cu, and limited cell loss. These data suggest that regions affected by α-synuclein pathology may display enhanced vulnerability and cell loss if Cu-dependent protective mechanisms are compromised. Additional investigation of copper pathology in PD may identify novel targets for the development of protective therapies for this disorder. | |
dc.language.iso | en | |
dc.title.en | Copper pathology in vulnerable brain regions in Parkinson's disease. | |
dc.title.en | Copper pathology in PD | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.neurobiolaging.2013.09.034 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | |
bordeaux.journal | Neurobiol Aging | |
bordeaux.page | 858-66 | |
bordeaux.volume | 35 | |
bordeaux.issue | 4 | |
bordeaux.peerReviewed | oui | |
hal.identifier | inserm-00968923 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//inserm-00968923v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurobiol%20Aging&rft.date=2014-04&rft.volume=35&rft.issue=4&rft.spage=858-66&rft.epage=858-66&rft.au=DAVIES,%20Katherine&BOHIC,%20Sylvain&CARMONA,%20Asunci%C3%B3n&ORTEGA,%20Richard&COTTAM,%20Veronica&rft.genre=article |
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