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Performance of a new atomistic geometrical model of the B-DNA configuration for DNA-radiation interaction simulations

dc.contributor.authorBERNAL, M.A.
dc.contributor.authorSIKANSI, D.
dc.contributor.authorCAVALCANTE, F.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorINCERTI, S.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorCHAMPION, C.
dc.contributor.authorIVANCHENKO, V.
dc.contributor.authorFRANCIS, Z.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorKARAMITROS, M.
dc.date.issued2014
dc.date.conference2013-09
dc.identifier.issn1742-6596
dc.description.abstractEnWe have recently developed an atomistic model of the B-DNA configuration, up to the 30-nm chromatin fiber. This model is intended to be used in Monte Carlo simulations of the DNA-radiation interaction, specifically in conjunction with the Geant4-DNA extension of the Geant4 Monte Carlo toolkit. In this work, 11449 parallel chromatin fibers have been arranged within a cube mimicking a cell nucleus containing about 6.5×109 base pairs. Each atom in the model is represented by a sphere with the corresponding van der Waals radius. Direct single, double and total DNA strand break yields due to the impact of protons and alpha particles with LET ranging from 4.57 to 207.1 keV/μm have been determined. Also, the corresponding site-hit probabilities have been calculated.
dc.language.isoen
dc.publisherIOP Publishing
dc.publisherIOP Science
dc.source.titleJournal of Physics: Conference Series
dc.title.enPerformance of a new atomistic geometrical model of the B-DNA configuration for DNA-radiation interaction simulations
dc.typeCommunication dans un congrès
dc.identifier.doi10.1088/1742-6596/490/1/012150
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
bordeaux.journalJournal of Physics: Conference Series
bordeaux.page012150
bordeaux.volume490
bordeaux.countryCZ
bordeaux.title.proceedingJournal of Physics: Conference Series
bordeaux.conference.cityPrague
bordeaux.peerReviewedoui
hal.identifierin2p3-00978289
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2013-09-05
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00978289v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Journal%20of%20Physics:%20Conference%20Series&rft.jtitle=Journal%20of%20Physics:%20Conference%20Series&rft.date=2014&rft.volume=490&rft.spage=012150&rft.epage=012150&rft.eissn=1742-6596&rft.issn=1742-6596&rft.au=BERNAL,%20M.A.&SIKANSI,%20D.&CAVALCANTE,%20F.&INCERTI,%20S.&CHAMPION,%20C.&rft.genre=unknown


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