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Single- and Double-Strand Breaks of Dry DNA Exposed to Protons at Bragg-Peak Energies

hal.structure.identifierLaboratoire de Physique des Rayonnements et Applications [LPRA]
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorSOUICI, Mounir
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorKHALIL, Talat T.
hal.structure.identifierLaboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie [ICube]
dc.contributor.authorMULLER, Dominique
hal.structure.identifierDépartement Recherches Subatomiques [DRS-IPHC]
dc.contributor.authorRAFFY, Quentin
hal.structure.identifierDépartement Recherches Subatomiques [DRS-IPHC]
dc.contributor.authorBARILLON, Rémi
hal.structure.identifierLaboratoire de Physique des Rayonnements et Applications [LPRA]
dc.contributor.authorBELAFRITES, Abdelfettah
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorCHAMPION, Christophe
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorFROMM, Michel
dc.date.issued2017
dc.identifier.issn1520-6106
dc.description.abstractEnUltrathin layers (<20 nm) of pBR322 plasmid DNA were deposited onto 2.5 μm thick polyester films and exposed to proton Bragg-peak energies (90–3000 keV) at various fluences. A quantitative analysis of radio-induced DNA damage is reported here in terms of single- and double-strand breaks (SSB and DSB, respectively). The corresponding yields as well as G-values and the cross sections exhibit fairly good agreement with the rare available data, stemming from close experimental conditions, namely, based on α particle irradiation. SSB/DSB rates appear to be linear when plotted against linear energy transfer (LET) in the whole energy range studied. All the data present a maximum in the 150–200 keV energy range; as for LET, it peaks at 90 keV. We also show that fragmentation starts to be significant for proton fluences greater than 1 × 1011 cm–2 at the Bragg-peak energies. Finally, we determine the average proton track radial extension, rmax, corresponding to an occupation probability of 100% DSB in the Bragg-peak region. The rmax values determined are in excellent agreement with the radial extensions of proton tracks determined by simulation approaches in water. When plotted as a function of LET, both SSB and DSB cross sections bend back at high LETs.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enProtons
dc.subject.enBragg-Peak
dc.subject.ensingle and double strand break
dc.subject.encross-section
dc.subject.enradiochemical yield
dc.subject.endamage yield
dc.subject.enclustered DNA damage
dc.title.enSingle- and Double-Strand Breaks of Dry DNA Exposed to Protons at Bragg-Peak Energies
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.jpcb.6b11060
dc.subject.halPhysique [physics]/Physique [physics]/Chimie-Physique [physics.chem-ph]
bordeaux.journalJournal of Physical Chemistry B
bordeaux.page497 - 507
bordeaux.volume121
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-01559863
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01559863v1
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