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Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorLAMPE, Nathanael
hal.structure.identifierLaboratoire Microorganismes : Génome et Environnement [LMGE]
dc.contributor.authorBIRON, David
hal.structure.identifierSchool of Mathematics and Physics [Belfast]
dc.contributor.authorBROWN, Jeremy M. C.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorINCERTI, Sébastien
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorMARIN, Pierre
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorMAIGNE, Lydia
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorSARRAMIA, David
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSEZNEC, Hervé
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorBRETON, Vincent
dc.date.issued2016-11-16
dc.identifier.issn1932-6203
dc.description.abstractEnAt very low radiation dose rates, the effects of energy depositions in cells by ionizing radiation is best understood stochastically, as ionizing particles deposit energy along tracks separated by distances often much larger than the size of cells. We present a thorough analysis of the stochastic impact of the natural radiative background on cells, focusing our attention on E. coli grown as part of a long term evolution experiment in both underground and surface laboratories. The chance per day that a particle track interacts with a cell in the surface laboratory was found to be 6 × 10−5 day−1, 100 times less than the expected daily mutation rate for E. coli under our experimental conditions. In order for the chance cells are hit to approach the mutation rate, a gamma background dose rate of 20 μGy hr−1 is predicted to be required.
dc.language.isoen
dc.publisherPublic Library of Science
dc.subject.enSimulation and modeling
dc.subject.enBacterial evolution
dc.subject.enPoint mutation
dc.subject.enRadiation
dc.subject.enIonizing radiation
dc.subject.enRadiobiology
dc.subject.enMuons
dc.subject.enNucleons
dc.title.enSimulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pone.0166364
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Protistologie
dc.subject.halPhysique [physics]
bordeaux.journalPLoS ONE
bordeaux.pagee0166364
bordeaux.volume11
bordeaux.issue11
bordeaux.peerReviewedoui
hal.identifierhal-01610267
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01610267v1
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