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Mechanistic DNA damage simulations in Geant4-DNA part 1: A parameter study in a simplified geometry

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierLaboratoire de Physique de Clermont [LPC]
dc.contributor.authorLAMPE, Nathanael
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorKARAMITROS, Mathieu
hal.structure.identifierLaboratoire de Physique de Clermont [LPC]
dc.contributor.authorBRETON, Vincent
dc.contributor.authorBROWN, Jeremy
dc.contributor.authorKYRIAKOU, Ioanna
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSAKATA, Dousatsu
hal.structure.identifierLaboratoire de Physique de Clermont [LPC]
dc.contributor.authorSARRAMIA, David
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sébastien
dc.date.issued2018
dc.description.abstractEnMechanistic modelling of DNA damage in Monte Carlo simulations is highly sensitive to the parameters that define DNA damage. In this work, we use a simple testing geometry to investigate how different choices of physics models and damage model parameters can change the estimation of DNA damage in a mechanistic DNA damage simulation built in Geant4-DNA. The choice of physics model can lead to variations by up to a factor of two in the yield of physically induced strand breaks, and the parameters that determine scavenging, and physical and chemical single strand break induction can have even larger consequences. Using low energy electrons as primary particles, a variety of parameters are tested in this geometry in order to arrive at a parameter set consistent with past simulation studies. We find that the modelling of scavenging can play an important role in determining results, and speculate that high-scavenging regimes, where only chemical radicals within 1 nm of DNA are simulated, could provide a good means of testing mechanistic DNA simulations
dc.language.isoen
dc.title.enMechanistic DNA damage simulations in Geant4-DNA part 1: A parameter study in a simplified geometry
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ejmp.2018.02.011
dc.subject.halPhysique [physics]
bordeaux.journalPhys.Medica
bordeaux.page135-145
bordeaux.volume48
bordeaux.peerReviewedoui
hal.identifierhal-01815247
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01815247v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Phys.Medica&rft.date=2018&rft.volume=48&rft.spage=135-145&rft.epage=135-145&rft.au=LAMPE,%20Nathanael&KARAMITROS,%20Mathieu&BRETON,%20Vincent&BROWN,%20Jeremy&KYRIAKOU,%20Ioanna&rft.genre=article


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