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dc.contributor.authorFRANCIS, Ziad
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sébastien
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorZEIN, Sara
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorLAMPE, Nathanael
dc.contributor.authorGUZMAN, Carlos
dc.contributor.authorDURANTE, Marco
dc.date.issued2021-01-07
dc.identifier.issn0033-7587
dc.description.abstractEnImmunization with an inactivated virus is one of the strategies currently being tested towards developing a SARS-CoV-2 vaccine. One of the methods used to inactivate viruses is exposure to high doses of ionizing radiation to damage their nucleic acids. Although gamma-rays effectively induce lesions in the RNA, envelope proteins are also highly damaged in the process. This in turn may alter their antigenic properties, affecting their capacity to induce an adaptive immune response able to confer effective protection. Here, we modelled the impact of sparsely and densely ionizing radiation on SARS-CoV-2 using the Monte Carlo toolkit Geant4-DNA. With a realistic 3D target virus model, we calculated the expected number of lesions in the spike and membrane proteins, as well as in the viral RNA. We show that gamma-rays produce significant spike protein damage, but densely ionizing charged particles induce less membrane damage for the same level of RNA lesions, because a single ion traversal through the nuclear envelope is sufficient to inactivate the virus. We propose that accelerated charged particles produce inactivated viruses with little structural damage to envelope proteins, thereby representing a new and effective tool for developing vaccines against SARS-CoV-2 and other enveloped viruses.
dc.language.isoen
dc.publisherRadiation Research Society
dc.title.enMonte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development
dc.typeArticle de revue
dc.identifier.doi10.1667/RADE-20-00241.1
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
dc.identifier.arxiv2005.06201
bordeaux.journalRadiation Research
bordeaux.page221-229
bordeaux.volume195
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-03147585
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03147585v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Radiation%20Research&rft.date=2021-01-07&rft.volume=195&rft.issue=3&rft.spage=221-229&rft.epage=221-229&rft.eissn=0033-7587&rft.issn=0033-7587&rft.au=FRANCIS,%20Ziad&INCERTI,%20S%C3%A9bastien&ZEIN,%20Sara&LAMPE,%20Nathanael&GUZMAN,%20Carlos&rft.genre=article


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