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A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast

dc.contributor.authorSHIN, Wook-Geun
dc.contributor.authorSAKATA, Dousatsu
dc.contributor.authorLAMPE, Nathanael
dc.contributor.authorBELOV, Oleg
dc.contributor.authorTRAN, Ngoc Hoang
dc.contributor.authorPETROVIC, Ivan
dc.contributor.authorRISTIC-FIRA, Aleksandra
dc.contributor.authorDORDEVIC, Milos
dc.contributor.authorBERNAL, Mario
dc.contributor.authorBORDAGE, Marie-Claude
dc.contributor.authorFRANCIS, Ziad
dc.contributor.authorKYRIAKOU, Ioanna
hal.structure.identifierLaboratoire de dosimétrie des rayonnements ionisants [IRSN/PSE-SANTE/SDOS/LDRI]
dc.contributor.authorPERROT, Yann
dc.contributor.authorSASAKI, Takashi
hal.structure.identifierLaboratoire de dosimétrie des rayonnements ionisants [IRSN/PSE-SANTE/SDOS/LDRI]
dc.contributor.authorVILLAGRASA, Carmen
dc.contributor.authorGUATELLI, Susanna
dc.contributor.authorBRETON, Vincent
dc.contributor.authorEMFIETZOGLOU, Dimitris
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sebastien
dc.date.issued2021-10
dc.identifier.issn2072-6694
dc.description.abstractEnAccurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enA Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast
dc.typeArticle de revue
dc.identifier.doi10.3390/cancers13194940
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
bordeaux.journalCancers
bordeaux.page4940
bordeaux.volume13
bordeaux.issue19
bordeaux.peerReviewedoui
hal.identifierhal-03363166
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03363166v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2021-10&rft.volume=13&rft.issue=19&rft.spage=4940&rft.epage=4940&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=SHIN,%20Wook-Geun&SAKATA,%20Dousatsu&LAMPE,%20Nathanael&BELOV,%20Oleg&TRAN,%20Ngoc%20Hoang&rft.genre=article


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