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Characterization of MIRCOM, IRSN’s new ion microbeam dedicated to targeted irradiation of living biological samples

hal.structure.identifierLaboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons [IRSN/PSE-SANTE/SDOS/LMDN]
dc.contributor.authorVIANNA-LEGROS, Francois
hal.structure.identifierLaboratoire de Radiobiologie des expositions accidentelles [IRSN/PSE-SANTE/SERAMED/LRAcc]
dc.contributor.authorGONON, Geraldine
hal.structure.identifierLaboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons [IRSN/PSE-SANTE/SDOS/LMDN]
dc.contributor.authorLALANNE, Kevin
hal.structure.identifierLaboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons [IRSN/PSE-SANTE/SDOS/LMDN]
dc.contributor.authorADAM-GUILLERMIN, Christelle
hal.structure.identifierPôle Santé Environnement - Direction Santé [IRSN/PSE-SANTE]
dc.contributor.authorBOTTOLLIER DEPOIS, Jean Francois
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorDAUDIN, Laurent
hal.structure.identifierLaboratoire de Radiobiologie des expositions accidentelles [IRSN/PSE-SANTE/SERAMED/LRAcc]
dc.contributor.authorDUGUE, Delphine
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMORETTO, Philippe
hal.structure.identifierLaboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons [IRSN/PSE-SANTE/SDOS/LMDN]
dc.contributor.authorPETIT, Michael
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSERANI, Laurent
hal.structure.identifierBusiness Unit - Développement commercial à l'international [IRSN/DAEI/BU-DCI]
dc.contributor.authorSUCH, Jean Marc
hal.structure.identifierLaboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons [IRSN/PSE-SANTE/SDOS/LMDN]
dc.contributor.authorGRESSIER, Vincent
dc.date.issued2022-01-29
dc.identifier.issn0168-583X
dc.description.abstractEnIon microbeams have emerged as a powerful tool in several domains of radiation biology. They have been used, for example, in the evaluation of environmental and occupational risks of exposure to low doses of ionizing radiation, or the study of temporal evolution of DNA damage and repair after irradiation of targeted (sub)cellular components, in cells or multicellular organisms. This paper reports the development and commissioning of the IRSN’s MIRCOM facility, constituted by a microbeam line and irradiation station, designed for targeted irradiation of living biological samples with a focused ion microbeam extracted in air. This equipment is able to provide protons, alpha particles, and heavier ions such as B, C, O, with energies up to a few MeV. The performances of the microbeam have been assessed, in a first step, with 4 MeV protons. The beam spot size has been evaluated on CR39 track detectors and living cells at 2.2 ± 0.3 µm, and the targeting accuracy of the system has been measured using online time-lapse imaging at 2.1 ± 0.7 µm. The monitoring of the number of ions hitting the target can be carried out either by defining an appropriate beam opening time, thanks to a good beam stability and with regular beam monitoring between samples, or by placing thin ion detectors, currently under characterization, on the path of the beam for the lower numbers of ions. Future work will aim at improving the versatility of the MIRCOM facility, to be able to irradiate a wider variety of biological samples, from cellular to multicellular organisms.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.title.enCharacterization of MIRCOM, IRSN’s new ion microbeam dedicated to targeted irradiation of living biological samples
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nimb.2022.01.007
dc.subject.halPhysique [physics]
bordeaux.journalNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
bordeaux.page20-30
bordeaux.volume515
bordeaux.peerReviewedoui
hal.identifierhal-03550121
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03550121v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nuclear%20Instruments%20and%20Methods%20in%20Physics%20Research%20Section%20B:%20Beam%20Interactions%20with%20Materials%20and%20Atoms&rft.date=2022-01-29&rft.volume=515&rft.spage=20-30&rft.epage=20-30&rft.eissn=0168-583X&rft.issn=0168-583X&rft.au=VIANNA-LEGROS,%20Francois&GONON,%20Geraldine&LALANNE,%20Kevin&ADAM-GUILLERMIN,%20Christelle&BOTTOLLIER%20DEPOIS,%20Jean%20Francois&rft.genre=article


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