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Maternal depressive symptoms and children's cognitive school readiness: the role of gene-environment interplay

dc.rights.licenseopenen_US
dc.contributor.authorAHUN, Marilyn N.
dc.contributor.authorBRENDGEN, Mara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
dc.contributor.authorGIRARD, Alain
dc.contributor.authorVITARO, Frank
dc.contributor.authorTREMBLAY, Richard
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorDIONNE, Ginette
dc.date.accessioned2022-04-13T12:12:34Z
dc.date.available2022-04-13T12:12:34Z
dc.date.issued2022-03-19
dc.identifier.issn1435-1102 (Electronic) 1434-1816 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136632
dc.description.abstractEnMaternal depressive symptoms are a robust risk factor for poor cognitive outcomes in children, yet the role of gene-environment interplay in this association is not well understood. The objective of this study was to evaluate gene-environment interaction in the association between maternal depressive symptoms and children's cognitive school readiness. Data come from a population-based birth cohort of 538 twin pairs. Maternal depressive symptoms were self-reported (Centre for Epidemiologic Studies Depression Scale) when children were aged 6 and 18 months (a mean score was used). Children's cognitive school readiness was assessed using the Lollipop Test when children were aged 5 years. Analyses were conducted with structural equation modeling. Maternal depressive symptoms were correlated with children's cognitive school readiness (r = -0.10). Shared environmental factors explained most of the variance in children's cognitive school readiness (52%). The remaining variance was accounted for by genetic (30%) and nonshared environmental factors (18%). As the level of maternal depressive symptoms increased, the relative contribution of nonshared environmental factors to the variance in children's cognitive school readiness increased (0.14 [95% CI: 0.04 to 0.24]), whereas the relative contribution of genetic factors decreased (-0.28 [-0.64 to 0.08]). In contexts of elevated maternal depressive symptoms, environmental - and potentially modifiable - factors may be especially important for shaping children's cognitive outcomes. This suggests that interventions to improve the early childhood environment of children exposed to maternal depressive symptoms may improve their cognitive outcomes.
dc.language.isoENen_US
dc.subject.enMaternal depressive symptoms
dc.subject.enCognitive development
dc.subject.enGene-environment interaction
dc.title.enMaternal depressive symptoms and children's cognitive school readiness: the role of gene-environment interplay
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00737-022-01207-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35305160en_US
bordeaux.journalArchives of Women's Mental Healthen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFonds de Recherche du Québec-Société et Cultureen_US
bordeaux.identifier.funderIDFonds de Recherche du Québec - Santéen_US
bordeaux.identifier.funderIDCanadian Institutes of Health Researchen_US
bordeaux.identifier.funderIDCentre de recherche du CHU Sainte-Justineen_US
bordeaux.identifier.funderIDUniversité Lavalen_US
bordeaux.identifier.funderIDUniversité de Montréalen_US
hal.identifierhal-03640281
hal.version1
hal.date.transferred2022-04-13T12:12:36Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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