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Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes

dc.rights.licenseopenen_US
dc.contributor.authorMOORE, Amy
dc.contributor.authorMACHIELA, Mitchell J.
dc.contributor.authorMACHADO, Moara
dc.contributor.authorWANG, Sophia S.
dc.contributor.authorKANE, Eleanor
dc.contributor.authorSLAGER, Susan L.
dc.contributor.authorZHOU, Weiyin
dc.contributor.authorCARRINGTON, Mary
dc.contributor.authorLAN, Qing
dc.contributor.authorMILNE, Roger L.
dc.contributor.authorBIRMANN, Brenda M.
dc.contributor.authorADAMI, Hans Olov
dc.contributor.authorALBANES, Demetrius
dc.contributor.authorARSLAN, Alan A.
dc.contributor.authorBECKER, Nikolaus
dc.contributor.authorBENAVENTE, Yolanda
dc.contributor.authorBISANZI, Simonetta
dc.contributor.authorBOFFETTA, Paolo
dc.contributor.authorBRACCI, Paige M.
dc.contributor.authorBRENNAN, Paul
dc.contributor.authorBROOKS-WILSON, Angela R.
dc.contributor.authorCANZIAN, Frederico
dc.contributor.authorCAPORASO, Neil
dc.contributor.authorCLAVEL, Jacqueline
dc.contributor.authorCOCCO, Pierluigi
dc.contributor.authorCONDE, Lucia
dc.contributor.authorCOX, David G.
dc.contributor.authorCOZEN, Wendy
dc.contributor.authorCURTIN, Karen
dc.contributor.authorDE VIVO, Immaculata
dc.contributor.authorDE SANJOSE, Silvia
dc.contributor.authorFORETOVA, Lenka
dc.contributor.authorGAPSTUR, Susan M.
dc.contributor.authorGHESQUIERES, Herve
dc.contributor.authorGILES, Graham G.
dc.contributor.authorGLENN, Martha
dc.contributor.authorGLIMELIUS, Bengt
dc.contributor.authorGAO, Chi
dc.contributor.authorHABERMANN, Thomas M.
dc.contributor.authorHJALGRIM, Henrik
dc.contributor.authorJACKSON, Rebecca D.
dc.contributor.authorLIEBOW, Mark
dc.contributor.authorLINK, Brian K.
dc.contributor.authorMAYNADIE, Marc
dc.contributor.authorMCKAY, James
dc.contributor.authorMELBYE, Mads
dc.contributor.authorMILIGI, Lucia
dc.contributor.authorMOLINA, Thierry J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorNIETERS, Alexandra
dc.contributor.authorNORTH, Kari E.
dc.contributor.authorOFFIT, Kenneth
dc.contributor.authorPATEL, Alpa V.
dc.contributor.authorPIRO, Sara
dc.contributor.authorRAVICHANDRAN, Vignesh
dc.contributor.authorRIBOLI, Elio
dc.contributor.authorSALLES, Gilles
dc.contributor.authorSEVERSON, Richard K.
dc.contributor.authorSKIBOLA, Christine F.
dc.contributor.authorSMEDBY, Karin E.
dc.contributor.authorSOUTHEY, Melissa C.
dc.contributor.authorSPINELLI, John J.
dc.contributor.authorSTAINES, Anthony
dc.contributor.authorSTEWART, Carolyn
dc.contributor.authorTERAS, Lauren R.
dc.contributor.authorTINKER, Lesley F.
dc.contributor.authorTRAVIS, Ruth C.
dc.contributor.authorVAJDIC, Claire M.
dc.contributor.authorVERMEULEN, Roel C. H.
dc.contributor.authorVIJAI, Joseph
dc.contributor.authorWEIDERPASS, Elisabete
dc.contributor.authorWEINSTEIN, Stephanie
dc.contributor.authorDOO, Nicole Wong
dc.contributor.authorZHANG, Yawei
dc.contributor.authorZHENG, Tongzhang
dc.contributor.authorCHANOCK, Stephen J.
dc.contributor.authorROTHMAN, Nathaniel
dc.contributor.authorCERHAN, James R.
dc.contributor.authorDEAN, Michael
dc.contributor.authorCAMP, Nicola J.
dc.contributor.authorYEAGER, Meredith
dc.contributor.authorBERNDT, Sonja I.
dc.date.accessioned2022-04-13T11:09:19Z
dc.date.available2022-04-13T11:09:19Z
dc.date.issued2021-10
dc.identifier.issn2578-5281 (Online)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136629
dc.description.abstractEnAIM: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk. METHODS: We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis. RESULTS: We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, P = 1.6 × 10(-6)) and FL (β = 11.4, SE = 5.82, P = 0.02) but not DLBCL (P = 1.0) or MZL (P = 0.91). For F3, we observed an association with CLL (β = 27.5, SE = 6.51, P = 2.4 × 10(-5)). We did not find evidence of associations with specific ROH, suggesting that the associations observed with FROH and F3 for CLL and FL risk were not driven by a single region of homozygosity. CONCLUSION: Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enNon-Hodgkin lymphoma
dc.subject.enHomozygosity
dc.subject.enChronic lymphocytic leukemia
dc.subject.enFollicular lymphoma
dc.subject.enDiffuse large B-cell lymphoma
dc.subject.enMarginal zone lymphoma
dc.title.enGenome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes
dc.typeArticle de revueen_US
dc.identifier.doi10.20517/jtgg.2021.08en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34622145en_US
bordeaux.journalJournal of translational genetics and genomicsen_US
bordeaux.page200-217en_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
hal.identifierhal-03962314
hal.version1
hal.date.transferred2023-01-30T09:31:13Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20translational%20genetics%20and%20genomics&rft.date=2021-10&rft.volume=5&rft.spage=200-217&rft.epage=200-217&rft.eissn=2578-5281%20(Online)&rft.issn=2578-5281%20(Online)&rft.au=MOORE,%20Amy&MACHIELA,%20Mitchell%20J.&MACHADO,%20Moara&WANG,%20Sophia%20S.&KANE,%20Eleanor&rft.genre=article


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