Structural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | KOUBIYR, Ismail | |
| dc.contributor.author | DELOIRE, Mathilde | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BROCHET, Bruno | |
| dc.contributor.author | BESSON, Pierre | |
| dc.contributor.author | CHARRE-MORIN, Julie | |
| dc.contributor.author | SAUBUSSE, Aurore | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TOURDIAS, Thomas | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | RUET, Aurelie | |
| dc.date.accessioned | 2022-03-15T16:25:50Z | |
| dc.date.available | 2022-03-15T16:25:50Z | |
| dc.date.issued | 2021-04 | |
| dc.identifier.issn | 1477-0970 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136468 | |
| dc.description.abstractEn | Background: The relationship between structural and functional deficits in multiple sclerosis (MS) is unclear. Objective: This study explored structure-function relationships during the 5 years following a clinically isolated syndrome and their role in cognitive performance. Methods: Thirty-two patients were enrolled after their first neurological episode suggestive of MS and followed for 5 years, along with 10 matched healthy controls. We assessed structural (using diffusion tensor imaging) and functional (using resting-state functional magnetic resonance imaging (fMRI)) brain network metrics, clinical and cognitive scores at each follow-up visit. Structural–functional coupling, calculated as the correlation coefficient between strengths of structural and functional networks, was used to assess structure–function relationships. Results: Structural clustering coefficient was significantly increased after 5 years, whereas characteristic path length decreased. Structural connections decreased after 1 year and increased after 5 years. Functional connections and related path lengths were decreased after 5 years. Structural–functional coupling had increased significantly after 5 years. This structural–functional coupling was associated with cognitive and clinical evolution, with stronger coupling associated with a decline in both domains. Conclusion: Our findings provide novel biological evidence that MS leads to a more constrained anatomical-dependant functional connectivity. The collapse of this network seems to lead to both cognitive worsening and clinical disability. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Clinically isolated syndrome | |
| dc.subject.en | Cognition | |
| dc.subject.en | Diffusion tensor imaging | |
| dc.subject.en | Functional MRI | |
| dc.subject.en | Graph theory | |
| dc.subject.en | Multiple sclerosis | |
| dc.title.en | Structural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis | |
| dc.title.alternative | Mult Scler | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/1352458520971807 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33283582 | en_US |
| bordeaux.journal | Multiple Sclerosis Journal | en_US |
| bordeaux.page | 559-567 | en_US |
| bordeaux.volume | 27 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03609682 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-03-15T16:25:52Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Multiple%20Sclerosis%20Journal&rft.date=2021-04&rft.volume=27&rft.issue=4&rft.spage=559-567&rft.epage=559-567&rft.eissn=1477-0970&rft.issn=1477-0970&rft.au=KOUBIYR,%20Ismail&DELOIRE,%20Mathilde&BROCHET,%20Bruno&BESSON,%20Pierre&CHARRE-MORIN,%20Julie&rft.genre=article |
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