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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOUBIYR, Ismail
dc.contributor.authorDELOIRE, Mathilde
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBROCHET, Bruno
dc.contributor.authorBESSON, Pierre
dc.contributor.authorCHARRE-MORIN, Julie
dc.contributor.authorSAUBUSSE, Aurore
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.date.accessioned2022-03-15T16:25:50Z
dc.date.available2022-03-15T16:25:50Z
dc.date.issued2021-04
dc.identifier.issn1477-0970en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136468
dc.description.abstractEnBackground: The relationship between structural and functional deficits in multiple sclerosis (MS) is unclear. Objective: This study explored structure-function relationships during the 5 years following a clinically isolated syndrome and their role in cognitive performance. Methods: Thirty-two patients were enrolled after their first neurological episode suggestive of MS and followed for 5 years, along with 10 matched healthy controls. We assessed structural (using diffusion tensor imaging) and functional (using resting-state functional magnetic resonance imaging (fMRI)) brain network metrics, clinical and cognitive scores at each follow-up visit. Structural–functional coupling, calculated as the correlation coefficient between strengths of structural and functional networks, was used to assess structure–function relationships. Results: Structural clustering coefficient was significantly increased after 5 years, whereas characteristic path length decreased. Structural connections decreased after 1 year and increased after 5 years. Functional connections and related path lengths were decreased after 5 years. Structural–functional coupling had increased significantly after 5 years. This structural–functional coupling was associated with cognitive and clinical evolution, with stronger coupling associated with a decline in both domains. Conclusion: Our findings provide novel biological evidence that MS leads to a more constrained anatomical-dependant functional connectivity. The collapse of this network seems to lead to both cognitive worsening and clinical disability.
dc.language.isoENen_US
dc.subject.enClinically isolated syndrome
dc.subject.enCognition
dc.subject.enDiffusion tensor imaging
dc.subject.enFunctional MRI
dc.subject.enGraph theory
dc.subject.enMultiple sclerosis
dc.title.enStructural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis
dc.title.alternativeMult Scleren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/1352458520971807en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33283582en_US
bordeaux.journalMultiple Sclerosis Journalen_US
bordeaux.page559-567en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03609682
hal.version1
hal.date.transferred2022-03-15T16:25:52Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Multiple%20Sclerosis%20Journal&rft.date=2021-04&rft.volume=27&rft.issue=4&rft.spage=559-567&rft.epage=559-567&rft.eissn=1477-0970&rft.issn=1477-0970&rft.au=KOUBIYR,%20Ismail&DELOIRE,%20Mathilde&BROCHET,%20Bruno&BESSON,%20Pierre&CHARRE-MORIN,%20Julie&rft.genre=article


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