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Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: the MEMENTO cohort study

dc.rights.licenseopenen_US
dc.contributor.authorREGY, Melina
dc.contributor.authorDUGRAVOT, Aline
dc.contributor.authorSABIA, Severine
dc.contributor.authorFAYOSSE, Aurore
dc.contributor.authorMANGIN, Jean-Francois
dc.contributor.authorCHUPIN, Marie
dc.contributor.authorFISCHER, Clara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorPAQUET, Claire
dc.contributor.authorHANSEEUW, Bernard
dc.contributor.authorSINGH-MANOUX, Archana
dc.contributor.authorDUMURGIER, Julien
dc.date.accessioned2022-03-11T15:52:45Z
dc.date.available2022-03-11T15:52:45Z
dc.date.issued2022-04-15
dc.identifier.issn1095-9572 (Electronic) 1053-8119 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136458
dc.description.abstractEnData on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional gray matter volumes in cross-sectional analysis and change therein using longitudinal analyses based on two brain MRI performed at baseline and at two-year follow-up. Overall, in analyses adjusted for age, sex, and intracranial volume, the presence of APOE4 was associated with lower total gray matter volume at baseline and with a higher atrophy rate over the follow-up. The hippocampus and entorhinal cortex were the two gray matter regions most associated with APOE4. Further adjustment for cardiovascular risk factors had little impact on these associations. There was an interaction between age, APOE4 status and total brain volume atrophy rate, with evidence of an earlier age at onset of atrophy in hippocampal volume in APOE4 carriers compared to non-carriers. Those results are in accordance with the role of medial temporal structures in the greater risk of dementia observed in people carrying the APOE4 allele.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAPOE genotype
dc.subject.enMRI
dc.subject.enLongitudinal analysis
dc.title.enAssociation of APOE ε4 with cerebral gray matter volumes in non-demented older adults: the MEMENTO cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuroimage.2022.118966en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35122970en_US
bordeaux.journalNeuroImageen_US
bordeaux.volume250en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.teamMEMENTOen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre Hospitalier Universitaire de Bordeauxen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.identifierhal-03606321
hal.version1
hal.date.transferred2022-03-11T15:52:48Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NeuroImage&rft.date=2022-04-15&rft.volume=250&rft.eissn=1095-9572%20(Electronic)%201053-8119%20(Linking)&rft.issn=1095-9572%20(Electronic)%201053-8119%20(Linking)&rft.au=REGY,%20Melina&DUGRAVOT,%20Aline&SABIA,%20Severine&FAYOSSE,%20Aurore&MANGIN,%20Jean-Francois&rft.genre=article


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