Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression
dc.rights.license | open | en_US |
dc.contributor.author | VANHERSECKE, Lucile | |
dc.contributor.author | BRUNET, Maxime | |
dc.contributor.author | GUEGAN, Jean-Philippe | |
dc.contributor.author | REY, Christophe | |
dc.contributor.author | BOUGOUIN, Antoine | |
dc.contributor.author | COUSIN, Sophie | |
dc.contributor.author | LE MOULEC, Sylvestre | |
dc.contributor.author | BESSE, Benjamin | |
dc.contributor.author | LORIOT, Yohann | |
dc.contributor.author | LARROQUETTE, Mathieu | |
dc.contributor.author | SOUBEYRAN, Isabelle | |
dc.contributor.author | TOULMONDE, Maud | |
dc.contributor.author | ROUBAUD, Guilhem | |
dc.contributor.author | PERNOT, Simon | |
dc.contributor.author | CABART, Mathilde | |
dc.contributor.author | CHOMY, Francois | |
dc.contributor.author | LEFEVRE, Corentin | |
dc.contributor.author | BOURCIER, Kevin | |
dc.contributor.author | KIND, Michele | |
dc.contributor.author | GIGLIOLI, Ilenia | |
dc.contributor.author | SAUTES-FRIDMAN, Catherine | |
dc.contributor.author | VELASCO, Valerie | |
dc.contributor.author | COURGEON, Felicie | |
dc.contributor.author | OFLAZOGLU, Ezoglin | |
dc.contributor.author | SAVINA, Ariel | |
dc.contributor.author | MARABELLE, Aurelien | |
dc.contributor.author | SORIA, Jean-Charles | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | BELLERA, Carine | |
dc.contributor.author | SOFEU, Casimir | |
dc.contributor.author | BESSEDE, Alban | |
dc.contributor.author | FRIDMAN, Wolf H. | |
dc.contributor.author | LE LOARER, Francois | |
dc.contributor.author | ITALIANO, Antoine | |
dc.date.accessioned | 2022-03-09T15:19:42Z | |
dc.date.available | 2022-03-09T15:19:42Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2662-1347 (Electronic) 2662-1347 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136408 | |
dc.description.abstractEn | Only a minority of patients derive long-term clinical benefit from anti-PD1/PD-L1 monoclonal antibodies. The presence of tertiary lymphoid structures (TLS) has been associated with improved survival in several tumor types. Here, using a large-scale retrospective analysis of three independent cohorts of cancer patients treated with anti-PD1/PD-L1 antibodies, we showed that the presence of mature TLS was associated with improved objective response rate, progression-free survival, and overall survival independently of PD-L1 expression status and CD8+ T-cell density. These results pave the way for using TLS detection to select patients who are more likely to benefit from immune checkpoint blockade. | |
dc.language.iso | EN | en_US |
dc.title.en | Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s43018-021-00232-6 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 35118423 | en_US |
bordeaux.journal | Nature Cancer | en_US |
bordeaux.page | 794-802 | en_US |
bordeaux.volume | 2 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 8 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | EPICENE_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | AstraZeneca | en_US |
hal.identifier | hal-03603101 | |
hal.version | 1 | |
hal.date.transferred | 2022-03-09T15:19:46Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Cancer&rft.date=2021&rft.volume=2&rft.issue=8&rft.spage=794-802&rft.epage=794-802&rft.eissn=2662-1347%20(Electronic)%202662-1347%20(Linking)&rft.issn=2662-1347%20(Electronic)%202662-1347%20(Linking)&rft.au=VANHERSECKE,%20Lucile&BRUNET,%20Maxime&GUEGAN,%20Jean-Philippe&REY,%20Christophe&BOUGOUIN,%20Antoine&rft.genre=article |
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