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Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

dc.rights.licenseopenen_US
dc.contributor.authorGONZALEZ-DOMINGUEZ, Raul
dc.contributor.authorCASTELLANO-ESCUDER, Pol
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorLOW, Dorrain Y.
dc.contributor.authorDU PREEZ, Andrea
dc.contributor.authorRUIGROK, Silvie R.
dc.contributor.authorLEE, Hyunah
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorPALLAS, Merce
dc.contributor.authorURPI-SARDA, Mireia
dc.contributor.authorSANCHEZ-PLA, Alex
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorLUCASSEN, Paul J.
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorMANACH, Claudine
dc.contributor.authorTHURET, Sandrine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorANDRES-LACUEVA, Cristina
dc.date.accessioned2022-03-04T14:16:56Z
dc.date.available2022-03-04T14:16:56Z
dc.date.issued2022-01-03
dc.identifier.issn1758-9193 (Electronic)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/128831
dc.description.abstractEnBACKGROUND: Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia, but the relationship between these metabolic disturbances and common risk factors, namely the ɛ4 allele of the apolipoprotein E (ApoE-ɛ4) gene and sex, remains elusive. METHODS: In order to investigate early alterations associated with cognitive decline in the fatty acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested case-control study (N=368), part of a prospective population cohort on dementia. RESULTS: When considering the entire study population, circulating levels of free fatty acids, acyl-carnitines and pantothenic acid were found to be increased among those participants who had greater odds of cognitive decline over a 12-year follow-up. Interestingly, stratified analyses indicated that these metabolomic alterations were specific for ApoE-ɛ4 non-carriers and women. CONCLUSIONS: Altogether, our results highlight that the regulation of fatty acids and related metabolic pathways during ageing and cognitive decline depends on complex inter-relationships between the ApoE-ε4 genotype and sex. A better understanding of the ApoE-ɛ4 and sex dependent modulation of metabolism is essential to elucidate the individual variability in the onset of cognitive decline, which would help develop personalized therapeutic approaches.
dc.description.sponsorshipIdentification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing-reversing cognitive declineen_US
dc.description.sponsorshipUniversity of Bordeaux Graduate School in Digital Public Healthen_US
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveauen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCognitive decline
dc.subject.enFatty acids
dc.subject.enApolipoprotein E
dc.subject.enSex
dc.subject.enAcyl-carnitines
dc.subject.enMetabolomics
dc.title.enApolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13195-021-00948-8en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34980257en_US
dc.description.sponsorshipEuropeA Healthy Diet for a Healthy Life - Coordination Actionen_US
dc.description.sponsorshipEuropeInvestissement d'aveniren_US
bordeaux.journalAlzheimer's Research and Therapyen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
hal.identifierhal-03597972
hal.version1
hal.date.transferred2022-03-04T14:17:00Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20Research%20and%20Therapy&rft.date=2022-01-03&rft.volume=14&rft.issue=1&rft.eissn=1758-9193%20(Electronic)&rft.issn=1758-9193%20(Electronic)&rft.au=GONZALEZ-DOMINGUEZ,%20Raul&CASTELLANO-ESCUDER,%20Pol&LEFEVRE%20ARBOGAST,%20Sophie&LOW,%20Dorrain%20Y.&DU%20PREEZ,%20Andrea&rft.genre=article


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