Targeting Pdzrn3 maintains adult blood-brain barrier and central nervous system homeostasis
| dc.rights.license | authentification | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | GUENIOT, Florian | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RUBIN, Sebastien | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | BOUGARAN, Pauline | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | ABELANET, Alice | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MOREL, Jean Luc
IDREF: 113377533 | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BONTEMPI, Bruno
IDREF: 119124459 | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | PROUST, Carole | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | DUFOURCQ, Pascale | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | COUFFINHAL, Thierry | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | DUPLÀA, Cecile | |
| dc.date.accessioned | 2022-02-03T16:36:24Z | |
| dc.date.available | 2022-02-03T16:36:24Z | |
| dc.date.issued | 2021-10-13 | |
| dc.identifier.issn | 1559-7016 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124668 | |
| dc.description.abstractEn | Blood brain barrier (BBB) disruption is a critical component of the pathophysiology of cognitive impairment of vascular etiology (VCI) and associated with Alzheimer's disease (AD). The Wnt pathway plays a crucial role in BBB maintenance, but there is limited data on its role in cognitive pathologies. The E3 ubiquitin ligase PDZRN3 is a regulator of the Wnt pathway. In a murine model of VCI, overexpressing in endothelial cell (EC) exacerbated BBB hyperpermeability and accelerated cognitive decline. We extended these observations, in both VCI and AD models, showing that EC-specific depletion of reinforced the BBB, with a decrease in vascular permeability and a subsequent spare in cognitive decline. We found that in cerebral vessels, Pdzrn3 depletion protects against AD-induced Wnt target gene alterations and enhances endothelial tight junctional proteins. Our results provide evidence that Wnt signaling could be a molecular link regulating BBB integrity and cognitive decline under VCI and AD pathologies. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Vascular cognitive impairment | |
| dc.subject.en | blood brain barrier | |
| dc.subject.en | vascular permeability | |
| dc.subject.en | Wnt pathway | |
| dc.subject.en | endothelial tight junction | |
| dc.title.en | Targeting Pdzrn3 maintains adult blood-brain barrier and central nervous system homeostasis | |
| dc.title.alternative | J Cereb Blood Flow Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/0271678X211048981 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire | en_US |
| dc.identifier.pubmed | 34644209 | en_US |
| bordeaux.journal | Journal of Cerebral Blood Flow and Metabolism | en_US |
| bordeaux.page | 271678X211048981 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03555717 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-02-03T16:36:27Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cerebral%20Blood%20Flow%20and%20Metabolism&rft.date=2021-10-13&rft.spage=271678X211048981&rft.epage=271678X211048981&rft.eissn=1559-7016&rft.issn=1559-7016&rft.au=GUENIOT,%20Florian&RUBIN,%20Sebastien&BOUGARAN,%20Pauline&ABELANET,%20Alice&MOREL,%20Jean%20Luc&rft.genre=article |
