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Prognostic Value of Routinely Measured Inflammatory Biomarkers in Older Cancer Patients: Pooled Analysis of Three Cohorts

dc.rights.licenseopenen_US
dc.contributor.authorOUBAYA, Nadia
hal.structure.identifierActions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
dc.contributor.authorSOUBEYRAN, Pierre
dc.contributor.authorREINALD, Nicoleta
hal.structure.identifierActions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
dc.contributor.authorFONCK, Marianne
dc.contributor.authorALLAIN, Mylene
dc.contributor.authorZEBACHI, Sonia
dc.contributor.authorHEITZ, Damien
dc.contributor.authorLAURENT, Marie
dc.contributor.authorDELATTRE, Cecile
dc.contributor.authorCAILLET, Philippe
dc.contributor.authorDAUBA, Jerome
dc.contributor.authorBASTUJI-GARIN, Sylvie
dc.contributor.authorALBRAND, Gilles
dc.contributor.authorBRINGUIER, Michael
dc.contributor.authorRAINFRAY, Muriel
dc.contributor.authorBRAIN, Etienne
hal.structure.identifierActions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
dc.contributor.authorGRELLETY, Thomas
dc.contributor.authorPAILLAUD, Elena
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
dc.contributor.authorCANOUI-POITRINE, Florence
dc.date.accessioned2022-01-24T09:35:59Z
dc.date.available2022-01-24T09:35:59Z
dc.date.issued2021-12-07
dc.identifier.issn2072-6694en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124599
dc.description.abstractEnBACKGROUND: The prognostic assessment of older cancer patients is complicated by their heterogeneity. We aimed to assess the prognostic value of routine inflammatory biomarkers. METHODS: A pooled analysis of prospective multicenter cohorts of cancer patients aged >/=70 was performed. We measured CRP and albumin, and calculated Glasgow Prognostic Score (GPS) and CRP/albumin ratio. The GPS has three levels (0 = CRP </= 10 mg/L, albumin >/= 35 g/L, i.e., normal values; 1 = one abnormal value; 2 = two abnormal values). One-year mortality was assessed using Cox models. Discriminative power was assessed using Harrell's C index (C) and net reclassification improvement (NRI). RESULTS: Overall, 1800 patients were analyzed (mean age: 79 +/- 6; males: 62%; metastases: 38%). The GPS and CRP/albumin ratio were independently associated with mortality in patients not at risk of frailty (hazard ratio [95% confidence interval] = 4.48 [2.03-9.89] for GPS1, 11.64 [4.54-29.81] for GPS2, and 7.15 [3.22-15.90] for CRP/albumin ratio > 0.215) and in patients at risk of frailty (2.45 [1.79-3.34] for GPS1, 3.97 [2.93-5.37] for GPS2, and 2.81 [2.17-3.65] for CRP/albumin ratio > 0.215). The discriminative power of the baseline clinical model (C = 0.82 [0.80-0.83]) was increased by adding GPS (C = 0.84 [0.82-0.85]; NRI events (NRI+) = 10% [2-16]) and CRP/albumin ratio (C = 0.83 [0.82-0.85]; NRI+ = 14% [2-17]). CONCLUSIONS: Routine inflammatory biomarkers add prognostic value to clinical factors in older cancer patients.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCancer
dc.subject.enOlder patients
dc.subject.enMortality
dc.subject.enBiomarkers
dc.title.enPrognostic Value of Routinely Measured Inflammatory Biomarkers in Older Cancer Patients: Pooled Analysis of Three Cohorts
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/cancers13246154en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34944774en_US
bordeaux.journalCancersen_US
bordeaux.page6154en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue24en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03540655
hal.version1
hal.date.transferred2022-01-24T09:36:06Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Cancers&amp;rft.date=2021-12-07&amp;rft.volume=13&amp;rft.issue=24&amp;rft.spage=6154&amp;rft.epage=6154&amp;rft.eissn=2072-6694&amp;rft.issn=2072-6694&amp;rft.au=OUBAYA,%20Nadia&amp;SOUBEYRAN,%20Pierre&amp;REINALD,%20Nicoleta&amp;FONCK,%20Marianne&amp;ALLAIN,%20Mylene&amp;rft.genre=article


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