Infectious Agents as Potential Drivers of α-Synucleinopathies.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LINARD DE GUERTECHIN, Morgane | |
| dc.contributor.author | RAVIER, Alix | |
| dc.contributor.author | MOUGUE, Louisa | |
| dc.contributor.author | GRGURINA, Iris | |
| dc.contributor.author | BOUTILLIER, Anne-Laurence | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| dc.contributor.author | BLANC, Frederic | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.date.accessioned | 2022-01-21T09:58:32Z | |
| dc.date.available | 2022-01-21T09:58:32Z | |
| dc.date.issued | 2022-01-18 | |
| dc.identifier.issn | 1531-8257 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124589 | |
| dc.description.abstractEn | α-synucleinopathies, encompassing Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are devastating neurodegenerative diseases for which available therapeutic options are scarce, mostly because of our limited understanding of their pathophysiology. Although these pathologies are attributed to an intracellular accumulation of the α-synuclein protein in the nervous system with subsequent neuronal loss, the trigger(s) of this accumulation is/are not clearly identified. Among the existing hypotheses, interest in the hypothesis advocating the involvement of infectious agents in the onset of these diseases is renewed. In this article, we aimed to review the ongoing relevant factors favoring and opposing this hypothesis, focusing on (1) the potential antimicrobial role of α-synuclein, (2) potential entry points of pathogens in regard to early symptoms of diverse α-synucleinopathies, (3) pre-existing literature reviews assessing potential associations between infectious agents and Parkinson's disease, (4) original studies assessing these associations for dementia with Lewy bodies and multiple system atrophy (identified through a systematic literature review), and finally (5) potential susceptibility factors modulating the effects of infectious agents on the nervous system. © 2022 International Parkinson and Movement Disorder Society. | |
| dc.description.sponsorship | Contribution des astrocytes aux troubles cognitifs induits par la protéine Tau neuronale dans la maladie d'Alzheimer - ANR-18-CE16-0008 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Dementia with Lewy bodies | |
| dc.subject.en | Multiple system atrophy | |
| dc.subject.en | Parkinson's disease | |
| dc.subject.en | α-synuclein | |
| dc.subject.en | Infections | |
| dc.title.en | Infectious Agents as Potential Drivers of α-Synucleinopathies. | |
| dc.title.alternative | Mov Disord | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/mds.28925 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
| dc.identifier.pubmed | 35040520 | en_US |
| bordeaux.journal | Movement Disorders | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
| bordeaux.identifier.funderID | Université de Strasbourg | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Association France Alzheimer | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03585772 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-02-23T12:47:31Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Movement%20Disorders&rft.date=2022-01-18&rft.eissn=1531-8257&rft.issn=1531-8257&rft.au=LINARD%20DE%20GUERTECHIN,%20Morgane&RAVIER,%20Alix&MOUGUE,%20Louisa&GRGURINA,%20Iris&BOUTILLIER,%20Anne-Laurence&rft.genre=article |
