Afficher la notice abrégée

Insights from the 4C-T Study suggest increased cardiovascular burden in girls with end stage kidney disease before and after kidney transplantation

dc.rights.licenseopenen_US
dc.contributor.authorSUGIANTO, Rizky I.
dc.contributor.authorMEMARAN, Nima
dc.contributor.authorSCHMIDT, Bernhard M. W.
dc.contributor.authorDOYON, Anke
dc.contributor.authorTHURN-VALSASSINA, Daniela
dc.contributor.authorALPAY, Harika
dc.contributor.authorANARAT, Ali
dc.contributor.authorARBEITER, Klaus
dc.contributor.authorAZUKAITIS, Karolis
dc.contributor.authorBAYAZIT, Aysun K.
dc.contributor.authorBULUT, Ipek K.
dc.contributor.authorCALISKAN, Salim
dc.contributor.authorCANPOLAT, Nur
dc.contributor.authorDUZOVA, Ali
dc.contributor.authorGELLERMAN, Jutta
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorHOMEYER, Denise
dc.contributor.authorLITWIN, Mieczyslaw
dc.contributor.authorMENCARELLI, Francesca
dc.contributor.authorOBRYCKI, Lukasz
dc.contributor.authorPARIPOVIC, Dusan
dc.contributor.authorRANCHIN, Bruno
dc.contributor.authorSHROFF, Rukshana
dc.contributor.authorTEGTBUR, Uwe
dc.contributor.authorVON DER BORN, Jeannine
dc.contributor.authorYILMAZ, Ebru
dc.contributor.authorQUERFELD, Uwe
dc.contributor.authorWUHL, Elke
dc.contributor.authorSCHAEFER, Franz
dc.contributor.authorMELK, Anette
dc.date.accessioned2022-01-20T09:50:54Z
dc.date.available2022-01-20T09:50:54Z
dc.date.issued2021-12-21
dc.identifier.issn0085-2538en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124447
dc.description.abstractEnMortality in children with kidney failure is higher in girls than boys with cardiovascular complications representing the most common causes of death. Pulse wave velocity (PWV), a measure of vascular stiffness, predicts cardiovascular mortality in adults. Here, PWV in children with kidney failure undergoing kidney replacement therapy was investigated to determine sex differences and potential contributing factors. Two-hundred-thirty-five children (80 girls; 34%) undergoing transplantation (150 pre-emptive, 85 with prior dialysis) having at least one PWV measurement pre- and/or post-transplantation from a prospective cohort were analyzed. Longitudinal analyses (median/maximum follow-up time of 6/9 years) were performed for PWV z-scores (PWVz) using linear mixed regression models and further stratified by the categories of time: pre-kidney replacement therapy and post-transplantation. PWVz significantly increased by 0.094 per year and was significantly higher in girls (PWVz +0.295) compared to boys, independent of the underlying kidney disease. During pre-kidney replacement therapy, an average estimated GFR decline of 4ml/min/1.73m(2) per year was associated with a PWVz increase of 0.16 in girls only. Higher diastolic blood pressure and low density lipoprotein were independently associated with higher PWVz during pre-kidney replacement therapy in both sexes. In girls post-transplantation, an estimated GFR decline of 4ml/min/1.73m(2) per year pre-kidney replacement therapy and a longer time (over 12 months) to transplantation were significantly associated with higher PWVz of 0.22 and of 0.57, respectively. PWVz increased further after transplantation and was positively associated with time on dialysis and diastolic blood pressure in both sexes. Thus, our findings demonstrate that girls with advanced chronic kidney disease are more susceptible to develop vascular stiffening compared to boys, this difference persist after transplantation and might contribute to higher mortality rates seen in girls with kidney failure.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enArteriosclerosis
dc.subject.enCardiovascular disease
dc.subject.enChildren
dc.subject.enChronic kidney disease
dc.subject.enGlomerular filtration rate
dc.subject.enKidney function decline
dc.subject.enPediatric kidney transplantation
dc.subject.enPulse wave velocity
dc.subject.enRisk factors
dc.subject.enTransplant outcomes
dc.title.enInsights from the 4C-T Study suggest increased cardiovascular burden in girls with end stage kidney disease before and after kidney transplantation
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.kint.2021.11.032en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34952099en_US
bordeaux.journalKidney Internationalen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03536954
hal.version1
hal.date.transferred2022-01-20T09:50:59Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Kidney%20International&rft.date=2021-12-21&rft.eissn=0085-2538&rft.issn=0085-2538&rft.au=SUGIANTO,%20Rizky%20I.&MEMARAN,%20Nima&SCHMIDT,%20Bernhard%20M.%20W.&DOYON,%20Anke&THURN-VALSASSINA,%20Daniela&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_CI_2021_Sugianto.pdf
Taille:
1.530Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée