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Lymphoma in HIV-2-infected patients in combination antiretroviral therapy era
| dc.rights.license | open | en_US |
| dc.contributor.author | RONCHETTI, Anne Marie | |
| dc.contributor.author | MATHERON, Sophie | |
| dc.contributor.author | GALICIER, Lionel | |
| dc.contributor.author | DAMOND, Florence | |
| dc.contributor.author | MAHJOUB, Nadia | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHAGHIL-BOISSIERE, Nathalie | |
| dc.contributor.author | MEIGNIN, Veronique | |
| dc.contributor.author | MECHAI, Frederic | |
| dc.contributor.author | SIMON, Francois | |
| dc.contributor.author | OKSENHENDLER, Eric | |
| dc.contributor.author | GERARD, Laurence | |
| dc.date.accessioned | 2022-01-17T09:12:16Z | |
| dc.date.available | 2022-01-17T09:12:16Z | |
| dc.date.issued | 2021-11-15 | |
| dc.identifier.issn | 1473-5571 (Electronic) 0269-9370 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124402 | |
| dc.description.abstractEn | OBJECTIVE: To describe lymphoma in HIV-2-infected patients and compare their characteristics with lymphoma in HIV-1-infected patients. DESIGN: Ancillary analysis from a single center prospective cohort of HIV-lymphoma. METHODS: We report on 16 patients with HIV-2-lymphoma diagnosed after 1996 and included in a prospective cohort of HIV lymphoma. Five additional HIV-2-infected patients coinfected with HIV-1 or/and HTLV-I (6 lymphomas) are separately reported. The incidence of lymphoma in HIV-2-infected patients was evaluated in the French multicentric HIV-2 cohort. RESULTS: Incidence of lymphoma in the French HIV-2 cohort was estimated as 0.6/1000 patient-years. In our series, the median CD4+ cell count was 166 × 106/l at the time of lymphoma diagnosis and 50% of patients had undetectable plasma HIV-2-RNA. Lymphomas were non-Hodgkin lymphoma (n = 12) and classical Hodgkin lymphoma (n = 4). Similarly to HIV-1-lymphoma, clinical presentation was aggressive in most cases. All but one patient received intensive chemotherapy. Complete remission was achieved in 13 cases and 1 patient relapsed. The overall survival was not statistically different from that observed in patients with HIV-1 lymphoma. The six additional lymphomas observed in five HIV-2-infected patients coinfected with HIV-1 or/and HTLV-I presented with similar clinical presentation but worse prognosis. CONCLUSION: Despite the lower pathogenicity of HIV-2, the risk of developing lymphoma seems to be close to that observed in HIV-1 population with similar lymphoma characteristics. Compared with HIV-1, HIV-2-infected patients developed lymphoma later in their life but at a similar CD4+ cell count level. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adult T cell leukemia-lymphoma | |
| dc.subject.en | Chemotherapy | |
| dc.subject.en | HIV-2 | |
| dc.subject.en | Hodgkin lymphoma | |
| dc.subject.en | HTLV-I infections | |
| dc.subject.en | Non-Hodgkin lymphoma | |
| dc.subject.en | Treatment outcome | |
| dc.title.en | Lymphoma in HIV-2-infected patients in combination antiretroviral therapy era | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/QAD.0000000000003015 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34231524 | en_US |
| bordeaux.journal | AIDS. Official journal of the international AIDS Society | en_US |
| bordeaux.page | 2299-2309 | en_US |
| bordeaux.volume | 35 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 14 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03528161 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-01-17T09:12:18Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2021-11-15&rft.volume=35&rft.issue=14&rft.spage=2299-2309&rft.epage=2299-2309&rft.eissn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.issn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.au=RONCHETTI,%20Anne%20Marie&MATHERON,%20Sophie&GALICIER,%20Lionel&DAMOND,%20Florence&MAHJOUB,%20Nadia&rft.genre=article |
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