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ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

dc.rights.licenseopenen_US
dc.contributor.authorPICHI, Francesco
dc.contributor.authorDOLZ-MARCO, Rosa
dc.contributor.authorFRANCIS, Jasmine H.
dc.contributor.authorAU, Adrian
dc.contributor.authorDAVIS, Janet L.
dc.contributor.authorFAWZI, Amani
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGATTOUSI, Sarra
dc.contributor.authorGOLDSTEIN, Debra A.
dc.contributor.authorKEANE, Pearse A.
dc.contributor.authorMISEROCCHI, Elisabetta
dc.contributor.authorMARCHESE, Alessandro
dc.contributor.authorOHNO-MATSUI, Kyoko
dc.contributor.authorSAGOO, Mandeep S.
dc.contributor.authorSMITH, Scott D.
dc.contributor.authorSOBOL, Ethan K.
dc.contributor.authorTASIOPOULOU, Anastasia
dc.contributor.authorYANG, Xialou
dc.contributor.authorSHIELDS, Carol L.
dc.contributor.authorFREUND, K. Bailey
dc.contributor.authorSARRAF, David
dc.date.accessioned2022-01-17T08:31:28Z
dc.date.available2022-01-17T08:31:28Z
dc.date.issued2022-06
dc.identifier.issn0002-9394en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124399
dc.description.abstractEnIMPORTANCE: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. OBJECTIVE: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. DESIGN: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). PARTICIPANTS: Patients with a diagnosis of biopsy-proven VRL imaged with OCT at presentation EXPOSURE: The ocular information, systemic information and multimodal retinal imaging findings were collected and studied. MAIN OUTCOME MEASURE: Characteristics of VRL on OCT RESULTS: A total of 182 eyes of 115 patients (63 women, mean age 65 years) were included in this study. The disease was bilateral in 81 (70%) patients, and mean baseline visual acuity (VA) was 0.2±0.89 logMAR (Snellen equivalent of 20/32). At baseline, 38 patients (33%) presented with isolated ocular involvement, 54 (45%) with associated central nervous system (CNS) involvement and 11 (10%) with other systemic lymphomatous involvement and an additional 12 (10%) patients presented with both CNS and other systemic involvement. On OCT, tumor infiltration was identified in various retinal layers including lesions in the sub-retinal pigment epithelium (RPE) compartment (91% of eyes), the subretinal compartment (43% of eyes) and the intraretinal compartment (7% of eyes). CONCLUSIONS AND RELEVANCE: OCT analysis of eyes with vitreoretinal lymphoma identified 3 main regions of retinal infiltration. Sub-RPE location, with or without subretinal infiltration, was the most common pattern of involvement whereas isolated intraretinal infiltration was the least common.
dc.language.isoENen_US
dc.title.enADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ajo.2021.11.023en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34843686en_US
bordeaux.journalAmerican Journal of Ophthalmologyen_US
bordeaux.page16-26
bordeaux.volume238
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03528091
hal.version1
hal.date.transferred2022-09-02T13:04:59Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Ophthalmology&rft.date=2022-06&rft.volume=238&rft.spage=16-26&rft.epage=16-26&rft.eissn=0002-9394&rft.issn=0002-9394&rft.au=PICHI,%20Francesco&DOLZ-MARCO,%20Rosa&FRANCIS,%20Jasmine%20H.&AU,%20Adrian&DAVIS,%20Janet%20L.&rft.genre=article


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