Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study
| dc.rights.license | open | en_US |
| dc.contributor.author | AMADOU, Amina | |
| dc.contributor.author | PRAUD, Delphine | |
| dc.contributor.author | COUDON, Thomas | |
| dc.contributor.author | DANJOU, Aurelie M. N. | |
| dc.contributor.author | FAURE, Elodie | |
| dc.contributor.author | DEYGAS, Floriane | |
| dc.contributor.author | GRASSOT, Leny | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LEFFONDRE, Karen
IDREF: 183599128 | |
| dc.contributor.author | SEVERI, Gianluca | |
| dc.contributor.author | SALIZZONI, Pietro | |
| dc.contributor.author | MANCINI, Francesca Romana | |
| dc.contributor.author | FERVERS, Beatrice | |
| dc.date.accessioned | 2022-01-06T11:17:04Z | |
| dc.date.available | 2022-01-06T11:17:04Z | |
| dc.date.issued | 2021-11-29 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124328 | |
| dc.description.abstractEn | Molecular studies suggest that cadmium due to its estrogenic properties, might play a role in breast cancer (BC) progression. However epidemiological evidence is limited. This study explored the association between long-term exposure to airborne cadmium and risk of BC by stage, grade of differentiation, and histological types at diagnosis. A nested case-control study of 4401 cases and 4401 matched controls was conducted within the French E3N cohort. A Geographic Information System (GIS)-based metric demonstrated to reliably characterize long-term environmental exposures was employed to evaluate airborne exposure to cadmium. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. There was no relationship between cadmium exposure and stage of BC. Also, no association between cadmium exposure and grade of differentiation of BC was observed. However, further analyses by histological type suggested a positive association between cadmium and risk of invasive tubular carcinoma (ITC) BC [ORQ5 vs Q1 = 3.4 (95% CI 1.1-10.7)]. The restricted cubic spline assessment suggested a dose-response relationship between cadmium and ITC BC subtype. Our results do not support the hypothesis that airborne cadmium exposure may play a role in advanced BC risk, but suggest that cadmium may be associated with an increased risk of ITC. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41598-021-01243-0 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34845239 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 23088 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence de la transition écologique | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| bordeaux.identifier.funderID | Région Auvergne-Rhône-Alpes | en_US |
| bordeaux.identifier.funderID | Fondation ARC pour la Recherche sur le Cancer | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Institut Gustave-Roussy | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2021-11-29&rft.volume=11&rft.issue=1&rft.spage=23088&rft.epage=23088&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=AMADOU,%20Amina&PRAUD,%20Delphine&COUDON,%20Thomas&DANJOU,%20Aurelie%20M.%20N.&FAURE,%20Elodie&rft.genre=article |
