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Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

dc.rights.licenseopenen_US
dc.contributor.authorNGUYEN, Claire
dc.contributor.authorMONDOLONI, Sarah
dc.contributor.authorLE BORGNE, Tinaig
dc.contributor.authorCENTENO, Ines
dc.contributor.authorCOME, Maxime
dc.contributor.authorJEHL, Joachim
dc.contributor.authorSOLIE, Clement
dc.contributor.authorREYNOLDS, Lauren M.
dc.contributor.authorDURAND-DE CUTTOLI, Romain
dc.contributor.authorTOLU, Stefania
dc.contributor.authorVALVERDE, Sebastien
dc.contributor.authorDIDIENNE, Steve
dc.contributor.authorHANNESSE, Bernadette
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFIANCETTE, Jean-Francois
dc.contributor.authorPONS, Stephanie
dc.contributor.authorMASKOS, Uwe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDEROCHE-GAMONET, Veronique
IDREF: 119544008
dc.contributor.authorDALKARA, Deniz
dc.contributor.authorHARDELIN, Jean Pierre
dc.contributor.authorMOUROT, Alexandre
dc.contributor.authorMARTI, Fabio
dc.contributor.authorFAURE, Philippe
dc.date.accessioned2021-12-21T14:21:48Z
dc.date.available2021-12-21T14:21:48Z
dc.date.issued2021-08-18
dc.identifier.issn0896-6273en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124294
dc.description.abstractEnNicotine stimulates dopamine (DA) neurons of the ventral tegmental area (VTA) to establish and maintain reinforcement. Nicotine also induces anxiety through an as yet unknown circuitry. We found that nicotine injection drives opposite functional responses of two distinct populations of VTA DA neurons with anatomically segregated projections: it activates neurons that project to the nucleus accumbens (NAc), whereas it inhibits neurons that project to the amygdala nuclei (Amg). We further show that nicotine mediates anxiety-like behavior by acting on ?2-subunit-containing nicotinic acetylcholine receptors of the VTA. Finally, using optogenetics, we bidirectionally manipulate the VTA-NAc and VTA-Amg pathways to dissociate their contributions to anxiety-like behavior. We show that inhibition of VTA-Amg DA neurons mediates anxiety-like behavior, while their activation prevents the anxiogenic effects of nicotine. These distinct subpopulations of VTA DA neurons with opposite responses to nicotine may differentially drive the anxiogenic and the reinforcing effects of nicotine.
dc.language.isoENen_US
dc.subject.enAddiction
dc.subject.enAmygdala
dc.subject.enDopamine circuits
dc.subject.enJuxtacellular recordings
dc.subject.enNicotine
dc.subject.enNicotinic acetylcholine receptors
dc.subject.enNucleus accumbens
dc.subject.enOptogenetics
dc.subject.enVentral tegmental area
dc.title.enNicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuron.2021.06.013en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34242565en_US
bordeaux.journalNeuronen_US
bordeaux.page2604-2615.e9en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue16en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierpasteur-03300623
hal.version1
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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