Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19
| dc.rights.license | open | en_US |
| dc.contributor.author | LE, Trang T. | |
| dc.contributor.author | GUTIERREZ-SACRISTAN, Alba | |
| dc.contributor.author | SON, Jiyeon | |
| dc.contributor.author | HONG, Chuan | |
| dc.contributor.author | SOUTH, Andrew M. | |
| dc.contributor.author | BEAULIEU-JONES, Brett K. | |
| dc.contributor.author | LOH, Ne Hooi Will | |
| dc.contributor.author | LUO, Yuan | |
| dc.contributor.author | MORRIS, Michele | |
| dc.contributor.author | NGIAM, Kee Yuan | |
| dc.contributor.author | PATEL, Lay P. | |
| dc.contributor.author | SAMAYAMUTHU, Malarkodi J. | |
| dc.contributor.author | SCHRIVER, Emily | |
| dc.contributor.author | TAN, Amelia L. M. | |
| dc.contributor.author | MOORE, Jason | |
| dc.contributor.author | CAI, Tianxi | |
| dc.contributor.author | OMENN, Gilbert S. | |
| dc.contributor.author | AVILLACH, Paul | |
| dc.contributor.author | KOHANE, Isaac S. | |
| dc.contributor.author | CONSORTIUM FOR CLINICAL CHARACTERIZATION OF, Covid-By E. H. R. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | JOUHET, Vianney | |
| dc.contributor.author | VISWESWARAN, Shyam | |
| dc.contributor.author | MOWERY, Danielle L. | |
| dc.contributor.author | XIA, Zongqi | |
| dc.date.accessioned | 2021-12-08T15:44:30Z | |
| dc.date.available | 2021-12-08T15:44:30Z | |
| dc.date.issued | 2021-10-12 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124061 | |
| dc.description.abstractEn | Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January-September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7-7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7-10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19-25%), cerebrovascular diseases (24%, 13-35%), nontraumatic intracranial hemorrhage (34%, 20-50%), encephalitis and/or myelitis (37%, 17-60%) and myopathy (72%, 67-77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41598-021-99481-9 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34642371 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 20238 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Coll-ERIAS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | National Cancer Institute | en_US |
| hal.identifier | hal-03471113 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-12-08T15:44:35Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2021-10-12&rft.volume=11&rft.issue=1&rft.spage=20238&rft.epage=20238&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=LE,%20Trang%20T.&GUTIERREZ-SACRISTAN,%20Alba&SON,%20Jiyeon&HONG,%20Chuan&SOUTH,%20Andrew%20M.&rft.genre=article |
