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Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

dc.rights.licenseopenen_US
dc.contributor.authorLE, Trang T.
dc.contributor.authorGUTIERREZ-SACRISTAN, Alba
dc.contributor.authorSON, Jiyeon
dc.contributor.authorHONG, Chuan
dc.contributor.authorSOUTH, Andrew M.
dc.contributor.authorBEAULIEU-JONES, Brett K.
dc.contributor.authorLOH, Ne Hooi Will
dc.contributor.authorLUO, Yuan
dc.contributor.authorMORRIS, Michele
dc.contributor.authorNGIAM, Kee Yuan
dc.contributor.authorPATEL, Lay P.
dc.contributor.authorSAMAYAMUTHU, Malarkodi J.
dc.contributor.authorSCHRIVER, Emily
dc.contributor.authorTAN, Amelia L. M.
dc.contributor.authorMOORE, Jason
dc.contributor.authorCAI, Tianxi
dc.contributor.authorOMENN, Gilbert S.
dc.contributor.authorAVILLACH, Paul
dc.contributor.authorKOHANE, Isaac S.
dc.contributor.authorCONSORTIUM FOR CLINICAL CHARACTERIZATION OF, Covid-By E. H. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJOUHET, Vianney
dc.contributor.authorVISWESWARAN, Shyam
dc.contributor.authorMOWERY, Danielle L.
dc.contributor.authorXIA, Zongqi
dc.date.accessioned2021-12-08T15:44:30Z
dc.date.available2021-12-08T15:44:30Z
dc.date.issued2021-10-12
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124061
dc.description.abstractEnNeurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January-September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7-7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7-10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19-25%), cerebrovascular diseases (24%, 13-35%), nontraumatic intracranial hemorrhage (34%, 20-50%), encephalitis and/or myelitis (37%, 17-60%) and myopathy (72%, 67-77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enMultinational characterization of neurological phenotypes in patients hospitalized with COVID-19
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-021-99481-9en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34642371en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page20238en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamColl-ERIASen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Cancer Instituteen_US
hal.identifierhal-03471113
hal.version1
hal.date.transferred2021-12-08T15:44:35Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Scientific%20Reports&amp;rft.date=2021-10-12&amp;rft.volume=11&amp;rft.issue=1&amp;rft.spage=20238&amp;rft.epage=20238&amp;rft.eissn=2045-2322&amp;rft.issn=2045-2322&amp;rft.au=LE,%20Trang%20T.&amp;GUTIERREZ-SACRISTAN,%20Alba&amp;SON,%20Jiyeon&amp;HONG,%20Chuan&amp;SOUTH,%20Andrew%20M.&amp;rft.genre=article


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