Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | OUATTARA, Eric | |
| dc.contributor.author | BRUANDET, Amelie | |
| dc.contributor.author | BORDE, Aurelie | |
| dc.contributor.author | LENNE, Xavier | |
| dc.contributor.author | BINDER-FOUCARD, Florence | |
| dc.contributor.author | LE-BOURHIS-ZAIMI, Maggie | |
| dc.contributor.author | MULLER, Joris | |
| dc.contributor.author | TRAN BA LOC, Pierre | |
| dc.contributor.author | SEGURET, Fabienne | |
| dc.contributor.author | TEZENAS DU MONTCEL, Sophie | |
| dc.contributor.author | GILLERON, Veronique | |
| dc.date.accessioned | 2021-12-02T10:26:58Z | |
| dc.date.available | 2021-12-02T10:26:58Z | |
| dc.date.issued | 2021-10 | |
| dc.identifier.issn | 2052-4439 (Electronic) 2052-4439 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123974 | |
| dc.description.abstractEn | OBJECTIVE: To explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or a hospital care unit (HCU). DESIGN: Retrospective cohort analysis using the French national (Programme de médicalisation des systèmes d'information) database. SETTING: Any public or private hospital in France. PARTICIPANTS: 98 366 patients admitted with COVID-19 for more than 1 day during the first semester of 2020 were included. The underlying conditions were retrieved for all contiguous stays. MAIN OUTCOME MEASURES: In-hospital mortality and associated risk factors were assessed using frailty Cox models. RESULTS: Among the 98 366 patients included, 25 765 (26%) were admitted to a CCU. The median age was 66 (IQR: 55-76) years in CCUs and 74 (IQR: 57-85) years in HCUs. Age was the main risk factor of death in both CCUs and HCUs, with adjusted HRs (aHRs) in CCUs increasing from 1.60 (95% CI 1.35 to 1.88) for 46 to 65 years to 8.17 (95% CI 6.86 to 9.72) for ≥85 years. In HCUs, the aHR associated with age was more than two times higher. The gender was not significantly associated with death, aHR 1.03 (95% CI 0.98 to 1.09, p=0.2693) in CCUs. Most of the underlying chronic conditions were risk factors for death, including malignant neoplasm (CCU: 1.34 (95% CI 1.25 to 1.43); HCU: 1.41 (95% CI 1.35 to 1.47)), cirrhosis without transplant (1.41 (95% CI 1.22 to 1.64); 1.27 (95% CI 1.12 to 1.45)) and dementia (1.30 (95% CI 1.16 to 1.46); 1.07 (95% CI 1.03 to 1.12)). CONCLUSION: This analysis confirms the role of age as the major risk factor of death in patients with COVID-19 irrespective to admission to critical care and therefore supports the current vaccination policies targeting older individuals. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Respiratory infection | |
| dc.subject.en | Viral infection. | |
| dc.title.en | Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1136/bmjresp-2021-001002 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34711641 | en_US |
| bordeaux.journal | BMJ open respiratory research | en_US |
| bordeaux.volume | 8 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ%20open%20respiratory%20research&rft.date=2021-10&rft.volume=8&rft.issue=1&rft.eissn=2052-4439%20(Electronic)%202052-4439%20(Linking)&rft.issn=2052-4439%20(Electronic)%202052-4439%20(Linking)&rft.au=OUATTARA,%20Eric&BRUANDET,%20Amelie&BORDE,%20Aurelie&LENNE,%20Xavier&BINDER-FOUCARD,%20Florence&rft.genre=article |
