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dc.rights.licenseopenen_US
dc.contributor.authorJOHNSON, Leigh F.
dc.contributor.authorKARIMINIA, Azar
dc.contributor.authorTRICKEY, Adam
dc.contributor.authorYIANNOUTSOS, Constantin T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEKOUEVI, Didier Koumavi
dc.contributor.authorMINGA, Albert K.
dc.contributor.authorPASCOM, Ana Roberta Pati
dc.contributor.authorHAN, Win Min
dc.contributor.authorZHANG, Lei
dc.contributor.authorALTHOFF, Keri N.
dc.contributor.authorREBEIRO, Peter F.
dc.contributor.authorMURENZI, Gad
dc.contributor.authorROSS, Jonathan
dc.contributor.authorHSIAO, Nei Yuan
dc.contributor.authorMARSH, Kimberly
dc.date.accessioned2021-11-30T11:16:50Z
dc.date.available2021-11-30T11:16:50Z
dc.date.issued2021-09
dc.identifier.issn1758-2652 (Electronic) 1758-2652 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123942
dc.description.abstractEnINTRODUCTION: The third of the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets is to achieve a 90% rate of viral suppression (HIV viral load <1000 HIV-1 RNA copies/ml) in patients on antiretroviral treatment (ART) by 2020. However, some countries use different thresholds when reporting viral suppression, and there is thus a need for an adjustment to standardize estimates to the <1000 threshold. We aim to propose such an adjustment, to support consistent monitoring of progress towards the "third 90" target. METHODS: We considered three possible distributions for viral loads in ART patients: Weibull, Pareto and reverse Weibull (imposing an upper limit but no lower limit on the log scale). The models were fitted to data on viral load distributions in ART patients in the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration (representing seven global regions) and the ART Cohort Collaboration (representing Europe), using separate random effects models for adults and children. The models were validated using data from the World Health Organization (WHO) HIV drug resistance report and the Brazilian national ART programme. RESULTS: Models were calibrated using 921,157 adult and 37,431 paediatric viral load measurements, over 2010-2019. The Pareto and reverse Weibull models provided the best fits to the data, but for all models, the "shape" parameters for the viral load distributions differed significantly between regions. The Weibull model performed best in the validation against the WHO drug resistance survey data, while the Pareto model produced uncertainty ranges that were too narrow, relative to the validation data. Based on these analyses, we recommend using the reverse Weibull model. For example, if a country reports an 80% rate of viral suppression at <200 copies/ml, this model estimates the proportion virally suppressed at <1000 copies/ml is 88.3% (0.80(0.56) ), with uncertainty range 85.5-90.6% (0.80(0.70) -0.80(0.44) ). CONCLUSIONS: Estimates of viral suppression can change substantially depending on the threshold used in defining viral suppression. It is, therefore, important that viral suppression rates are standardized to the same threshold for the purpose of assessing progress towards UNAIDS targets. We have proposed a simple adjustment that allows this, and this has been incorporated into UNAIDS modelling software.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAntiretroviral therapy
dc.subject.enHIV
dc.subject.enViral load
dc.title.enAchieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jia2.25776en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34546623en_US
bordeaux.journalJournal of the International AIDS Societyen_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issueSuppl 5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamIDLICen_US
bordeaux.teamPACCIen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institute on Alcohol Abuse and Alcoholismen_US
hal.identifierhal-03456915
hal.version1
hal.date.transferred2021-11-30T11:16:53Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20the%20International%20AIDS%20Society&amp;rft.date=2021-09&amp;rft.volume=24&amp;rft.issue=Suppl%205&amp;rft.eissn=1758-2652%20(Electronic)%201758-2652%20(Linking)&amp;rft.issn=1758-2652%20(Electronic)%201758-2652%20(Linking)&amp;rft.au=JOHNSON,%20Leigh%20F.&amp;KARIMINIA,%20Azar&amp;TRICKEY,%20Adam&amp;YIANNOUTSOS,%20Constantin%20T.&amp;EKOUEVI,%20Didier%20Koumavi&amp;rft.genre=article


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