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A Genotyping Study in Benin Comparing the Carriage of Plasmodium falciparum Infections Before Pregnancy and in Early Pregnancy: Story of a Persistent Infection
| dc.rights.license | open | en_US |
| dc.contributor.author | JAFARI-GUEMOURI, Sayeh | |
| dc.contributor.author | COURTOIS, Laura | |
| dc.contributor.author | MAMA, Atika | |
| dc.contributor.author | ROUAS, Baptiste | |
| dc.contributor.author | NETO BRAGA, Gabriel | |
| dc.contributor.author | ACCROMBESSI, Manfred | |
| dc.contributor.author | MASSOUGBODJI, Achille | |
| dc.contributor.author | DING, Xavier C. | |
| dc.contributor.author | TUIKUE NDAM, Nicaise | |
| dc.contributor.author | FIEVET, Nadine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BRIAND, Valerie | |
| dc.date.accessioned | 2021-11-08T14:50:38Z | |
| dc.date.available | 2021-11-08T14:50:38Z | |
| dc.date.issued | 2021-07-15 | |
| dc.identifier.issn | 1058-4838 (Print) 1058-4838 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123782 | |
| dc.description.abstractEn | BACKGROUND: Malaria infections in the first trimester of pregnancy are frequent and deleterious for both mother and child health. To investigate if these early infections are newly acquired or already present in the host, we assessed whether parasites detected before pregnancy and those detected in early pregnancy are the same infection. METHODS: We used data from the preconceptional "RECIPAL" study (Benin, 2014-2017). Sixty-three pregnant women of 411 included who had a malaria infection detected by quantitative polymerase chain reaction both before pregnancy and at the first antenatal care (ANC) visit were selected for this study. Two highly polymorphic markers, msp-2 and glurp, and a fragment-analysis method were used to enumerate the Plasmodium falciparum genotypes and to quantify their proportions within isolates. An infection was considered as persistent when identical msp-2 and glurp genotypes were found in the corresponding prepregnancy and early-pregnancy samples. RESULTS: The median time between the 2 malaria screenings was 3 months. The median gestational age at the first ANC visit was 6.4 weeks. Most infections before pregnancy were submicroscopic infections. Based on both msp-2 and glurp genotyping, the infection was similar before and in early pregnancy in 46% (29/63) of cases. CONCLUSIONS: Almost half of P. falciparum infections detected in the first trimester originate before pregnancy. Protecting young women from malaria infection before pregnancy might reduce the prevalence of malaria in early pregnancy and its related poor maternal and birth outcomes. | |
| dc.description.sponsorship | Impact du paludisme précoce au cours de la grossesse sur la croissance fœtale au Bénin - ANR-13-JSV1-0004 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Malaria | |
| dc.subject.en | Pregnancy | |
| dc.subject.en | Africa | |
| dc.subject.en | Genotyping techniques | |
| dc.subject.en | Polymerase chain reaction | |
| dc.title.en | A Genotyping Study in Benin Comparing the Carriage of Plasmodium falciparum Infections Before Pregnancy and in Early Pregnancy: Story of a Persistent Infection | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/cid/ciaa841 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32569359 | en_US |
| bordeaux.journal | Clinical Infectious Diseases | en_US |
| bordeaux.page | e355-e361 | en_US |
| bordeaux.volume | 73 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Bill and Melinda Gates Foundation | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.identifier | hal-03419618 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-08T14:50:46Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2021-07-15&rft.volume=73&rft.issue=2&rft.spage=e355-e361&rft.epage=e355-e361&rft.eissn=1058-4838%20(Print)%201058-4838&rft.issn=1058-4838%20(Print)%201058-4838&rft.au=JAFARI-GUEMOURI,%20Sayeh&COURTOIS,%20Laura&MAMA,%20Atika&ROUAS,%20Baptiste&NETO%20BRAGA,%20Gabriel&rft.genre=article |
