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Fibrinolysis during liver transplantation: analysis by the Thrombodynamics method

dc.rights.licenseauthentificationen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorROULLET, S.
dc.contributor.authorLABROUCHE, S.
dc.contributor.authorFREYBURGER, G.
dc.date.accessioned2020-11-10T11:47:03Z
dc.date.available2020-11-10T11:47:03Z
dc.date.issued2019-09
dc.identifier.issn0021-9746, 1472-4146en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/12202
dc.description.abstractEnAn issue in orthotopic liver transplantation (OLT) is the diagnosis of hyperfibrinolysis. The Thrombodynamics-4D assay (TD4D) is a videomicroscopy system allowing the dynamic analysis of fibrin clot. Fibrinolysis is highlighted by a change in clot intensity. The aim of this observational study was to evaluate the TD4D as a tool to diagnose fibrinolysis during OLT. Thirty consecutive patients were included. We studied a subset of 41 samples from 13 patients who demonstrated hyperfibrinolysis during OLT by global fibrinolytic capacity studied by the Lysis Timer (GFC/LT) and/or euglobulin clot lysis time (ECLT) and/or EXTEM maximum lysis (EXTEM ML) on ROTEM. Three samples exhibited fibrinolysis. They exhibited significantly shorter ECLT, higher lysis on EXTEM graphs, shorter GFC/LT clot lysis time and higher t-PA activity values. After adding urokinase, 13 samples exhibited fibrinolysis. In conclusion, TD4D allows the dynamic analysis of fibrin clot formation and lysis. It only recognises the most severe forms of hyperfibrinolysis during OLT.
dc.language.isoENen_US
dc.subjectArticle CLINIQUE
dc.title.enFibrinolysis during liver transplantation: analysis by the Thrombodynamics method
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/jclinpath-2018-205560en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalJournal of Clinical Pathologyen_US
bordeaux.page636–638en_US
bordeaux.volume72en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194454
hal.version1
hal.date.transferred2021-04-09T13:20:00Z
hal.exporttrue
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