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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

dc.rights.licenseopenen_US
dc.contributor.authorEVANGELOU, E.
dc.contributor.authorWARREN, H. R.
dc.contributor.authorMOSEN-ANSORENA, D.
dc.contributor.authorMIFSUD, B.
dc.contributor.authorPAZOKI, R.
dc.contributor.authorGAO, H.
dc.contributor.authorNTRITSOS, G.
dc.contributor.authorDIMOU, N.
dc.contributor.authorCABRERA, C. P.
dc.contributor.authorKARAMAN, I.
dc.contributor.authorNG, F. L.
dc.contributor.authorEVANGELOU, M.
dc.contributor.authorWITKOWSKA, K.
dc.contributor.authorTZANIS, E.
dc.contributor.authorHELLWEGE, J. N.
dc.contributor.authorGIRI, A.
dc.contributor.authorVELEZ EDWARDS, D. R.
dc.contributor.authorSUN, Y. V.
dc.contributor.authorCHO, K.
dc.contributor.authorGAZIANO, J. M.
dc.contributor.authorWILSON, P. W. F.
dc.contributor.authorTSAO, P. S.
dc.contributor.authorKOVESDY, C. P.
dc.contributor.authorESKO, T.
dc.contributor.authorMAGI, R.
dc.contributor.authorMILANI, L.
dc.contributor.authorALMGREN, P.
dc.contributor.authorBOUTIN, T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDING, J.
dc.contributor.authorGIULIANINI, F.
dc.contributor.authorHOLLIDAY, E. G.
dc.contributor.authorJACKSON, A. U.
dc.contributor.authorLI-GAO, R.
dc.contributor.authorLIN, W. Y.
dc.contributor.authorLUAN, J.
dc.contributor.authorMANGINO, M.
dc.contributor.authorOLDMEADOW, C.
dc.contributor.authorPRINS, B. P.
dc.contributor.authorQIAN, Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorSHAH, N.
dc.contributor.authorSURENDRAN, P.
dc.contributor.authorTHERIAULT, S.
dc.contributor.authorVERWEIJ, N.
dc.contributor.authorWILLEMS, S. M.
dc.contributor.authorZHAO, J. H.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorCONNELL, J.
dc.contributor.authorDE MUTSERT, R.
dc.contributor.authorDONEY, A. S. F.
dc.contributor.authorFARRALL, M.
dc.contributor.authorMENNI, C.
dc.contributor.authorMORRIS, A. D.
dc.contributor.authorNOORDAM, R.
dc.contributor.authorPARE, G.
dc.contributor.authorPOULTER, N. R.
dc.contributor.authorSHIELDS, D. C.
dc.contributor.authorSTANTON, A.
dc.contributor.authorTHOM, S.
dc.contributor.authorABECASIS, G.
dc.contributor.authorAMIN, N.
dc.contributor.authorARKING, D. E.
dc.contributor.authorAYERS, K. L.
dc.contributor.authorBARBIERI, C. M.
dc.contributor.authorBATINI, C.
dc.contributor.authorBIS, J. C.
dc.contributor.authorBLAKE, T.
dc.contributor.authorBOCHUD, M.
dc.contributor.authorBOEHNKE, M.
dc.contributor.authorBOERWINKLE, E.
dc.contributor.authorBOOMSMA, D. I.
dc.contributor.authorBOTTINGER, E. P.
dc.contributor.authorBRAUND, P. S.
dc.contributor.authorBRUMAT, M.
dc.contributor.authorCAMPBELL, A.
dc.contributor.authorCAMPBELL, H.
dc.contributor.authorCHAKRAVARTI, A.
dc.contributor.authorCHAMBERS, J. C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHAUHAN, Ganesh
dc.contributor.authorCIULLO, M.
dc.contributor.authorCOCCA, M.
dc.contributor.authorCOLLINS, F.
dc.contributor.authorCORDELL, H. J.
dc.contributor.authorDAVIES, G.
dc.contributor.authorBORST, M. H.
dc.contributor.authorGEUS, E. J.
dc.contributor.authorDEARY, I. J.
dc.contributor.authorDEELEN, J.
dc.contributor.authorDEL GRECO, M. F.
dc.contributor.authorDEMIRKALE, C. Y.
dc.contributor.authorDORR, M.
dc.contributor.authorEHRET, G. B.
dc.contributor.authorELOSUA, R.
dc.contributor.authorENROTH, S.
dc.contributor.authorERZURUMLUOGLU, A. M.
dc.contributor.authorFERREIRA, T.
dc.contributor.authorFRANBERG, M.
dc.contributor.authorFRANCO, O. H.
dc.contributor.authorGANDIN, I.
dc.contributor.authorGASPARINI, P.
dc.contributor.authorGIEDRAITIS, V.
dc.contributor.authorGIEGER, C.
dc.contributor.authorGIROTTO, G.
dc.contributor.authorGOEL, A.
dc.contributor.authorGOW, A. J.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorGUO, X.
dc.contributor.authorGYLLENSTEN, U.
dc.contributor.authorHAMSTEN, A.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorHARRIS, S. E.
dc.contributor.authorHARTMAN, C. A.
dc.contributor.authorHAVULINNA, A. S.
dc.contributor.authorHICKS, A. A.
dc.contributor.authorHOFER, E.
dc.contributor.authorHOFMAN, A.
dc.contributor.authorHOTTENGA, J. J.
dc.contributor.authorHUFFMAN, J. E.
dc.contributor.authorHWANG, S. J.
dc.contributor.authorINGELSSON, E.
dc.contributor.authorJAMES, A.
dc.contributor.authorJANSEN, R.
dc.contributor.authorJARVELIN, M. R.
dc.contributor.authorJOEHANES, R.
dc.contributor.authorJOHANSSON, A.
dc.contributor.authorJOHNSON, A. D.
dc.contributor.authorJOSHI, P. K.
dc.contributor.authorJOUSILAHTI, P.
dc.contributor.authorJUKEMA, J. W.
dc.contributor.authorJULA, A.
dc.contributor.authorKAHONEN, M.
dc.contributor.authorKATHIRESAN, S.
dc.contributor.authorKEAVNEY, B. D.
dc.contributor.authorKHAW, K. T.
dc.contributor.authorKNEKT, P.
dc.contributor.authorKNIGHT, J.
dc.contributor.authorKOLCIC, I.
dc.contributor.authorKOONER, J. S.
dc.contributor.authorKOSKINEN, S.
dc.contributor.authorKRISTIANSSON, K.
dc.contributor.authorKUTALIK, Z.
dc.contributor.authorLAAN, M.
dc.contributor.authorLARSON, M.
dc.contributor.authorLAUNER, L. J.
dc.contributor.authorLEHNE, B.
dc.contributor.authorLEHTIMAKI, T.
dc.contributor.authorLIEWALD, D. C. M.
dc.contributor.authorLIN, L.
dc.contributor.authorLIND, L.
dc.contributor.authorLINDGREN, C. M.
dc.contributor.authorLIU, Y.
dc.contributor.authorLOOS, R. J. F.
dc.contributor.authorLOPEZ, L. M.
dc.contributor.authorLU, Y.
dc.contributor.authorLYYTIKAINEN, L. P.
dc.contributor.authorMAHAJAN, A.
dc.contributor.authorMAMASOULA, C.
dc.contributor.authorMARRUGAT, J.
dc.contributor.authorMARTEN, J.
dc.contributor.authorMILANESCHI, Y.
dc.contributor.authorMORGAN, A.
dc.contributor.authorMORRIS, A. P.
dc.contributor.authorMORRISON, A. C.
dc.contributor.authorMUNSON, P. J.
dc.contributor.authorNALLS, M. A.
dc.contributor.authorNANDAKUMAR, P.
dc.contributor.authorNELSON, C. P.
dc.contributor.authorNIIRANEN, T.
dc.contributor.authorNOLTE, I. M.
dc.contributor.authorNUTILE, T.
dc.contributor.authorOLDEHINKEL, A. J.
dc.contributor.authorOOSTRA, B. A.
dc.contributor.authorO'REILLY, P. F.
dc.contributor.authorORG, E.
dc.contributor.authorPADMANABHAN, S.
dc.contributor.authorPALMAS, W.
dc.contributor.authorPALOTIE, A.
dc.contributor.authorPATTIE, A.
dc.contributor.authorPENNINX, Bwjh
dc.contributor.authorPEROLA, M.
dc.contributor.authorPETERS, A.
dc.contributor.authorPOLASEK, O.
dc.contributor.authorPRAMSTALLER, P. P.
dc.contributor.authorNGUYEN, Q. T.
dc.contributor.authorRAITAKARI, O. T.
dc.contributor.authorREN, M.
dc.contributor.authorRETTIG, R.
dc.contributor.authorRICE, K.
dc.contributor.authorRIDKER, P. M.
dc.contributor.authorRIED, J. S.
dc.contributor.authorRIESE, H.
dc.contributor.authorRIPATTI, S.
dc.contributor.authorROBINO, A.
dc.contributor.authorROSE, L. M.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorRUDAN, I.
dc.contributor.authorRUGGIERO, D.
dc.contributor.authorSABA, Y.
dc.contributor.authorSALA, C. F.
dc.contributor.authorSALOMAA, V.
dc.contributor.authorSAMANI, N. J.
dc.contributor.authorSARIN, A. P.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorSHRINE, N.
dc.contributor.authorSISCOVICK, D.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorSNIEDER, H.
dc.contributor.authorSOBER, S.
dc.contributor.authorSORICE, R.
dc.contributor.authorSTARR, J. M.
dc.contributor.authorSTOTT, D. J.
dc.contributor.authorSTRACHAN, D. P.
dc.contributor.authorSTRAWBRIDGE, R. J.
dc.contributor.authorSUNDSTROM, J.
dc.contributor.authorSWERTZ, M. A.
dc.contributor.authorTAYLOR, K. D.
dc.contributor.authorTEUMER, A.
dc.contributor.authorTOBIN, M. D.
dc.contributor.authorTOMASZEWSKI, M.
dc.contributor.authorTONIOLO, D.
dc.contributor.authorTRAGLIA, M.
dc.contributor.authorTROMPET, S.
dc.contributor.authorTUOMILEHTO, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorUITTERLINDEN, A. G.
dc.contributor.authorVAEZ, A.
dc.contributor.authorVAN DER MOST, P. J.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorVERGNAUD, A. C.
dc.contributor.authorVERWOERT, G. C.
dc.contributor.authorVITART, V.
dc.contributor.authorVOLKER, U.
dc.contributor.authorVOLLENWEIDER, P.
dc.contributor.authorVUCKOVIC, D.
dc.contributor.authorWATKINS, H.
dc.contributor.authorWILD, S. H.
dc.contributor.authorWILLEMSEN, G.
dc.contributor.authorWILSON, J. F.
dc.contributor.authorWRIGHT, A. F.
dc.contributor.authorYAO, J.
dc.contributor.authorZEMUNIK, T.
dc.contributor.authorZHANG, W.
dc.contributor.authorATTIA, J. R.
dc.contributor.authorBUTTERWORTH, A. S.
dc.contributor.authorCHASMAN, D. I.
dc.contributor.authorCONEN, D.
dc.contributor.authorCUCCA, F.
dc.contributor.authorDANESH, J.
dc.contributor.authorHAYWARD, C.
dc.contributor.authorHOWSON, J. M. M.
dc.contributor.authorLAAKSO, M.
dc.contributor.authorLAKATTA, E. G.
dc.contributor.authorLANGENBERG, C.
dc.contributor.authorMELANDER, O.
dc.contributor.authorMOOK-KANAMORI, D. O.
dc.contributor.authorPALMER, C. N. A.
dc.contributor.authorRISCH, L.
dc.contributor.authorSCOTT, R. A.
dc.contributor.authorSCOTT, R. J.
dc.contributor.authorSEVER, P.
dc.contributor.authorSPECTOR, T. D.
dc.contributor.authorVAN DER HARST, P.
dc.contributor.authorWAREHAM, N. J.
dc.contributor.authorZEGGINI, E.
dc.contributor.authorLEVY, D.
dc.contributor.authorMUNROE, P. B.
dc.contributor.authorNEWTON-CHEH, C.
dc.contributor.authorBROWN, M. J.
dc.contributor.authorMETSPALU, A.
dc.contributor.authorHUNG, A. M.
dc.contributor.authorO'DONNELL, C. J.
dc.contributor.authorEDWARDS, T. L.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorTZOULAKI, I.
dc.contributor.authorBARNES, M. R.
dc.contributor.authorWAIN, L. V.
dc.contributor.authorELLIOTT, P.
dc.contributor.authorCAULFIELD, M. J.
dc.date.accessioned2020-11-09T14:57:54Z
dc.date.available2020-11-09T14:57:54Z
dc.date.issued2018-10
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/12167
dc.description.abstractEnHigh blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.subject.enVINTAGE
dc.title.enGenetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-018-0205-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30224653en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page1412-1425en_US
bordeaux.volume50en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193866
hal.version1
hal.date.transferred2021-04-09T08:20:39Z
hal.exporttrue
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