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Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorBEISER, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Geneviève
dc.contributor.authorSESHADRI, Sudha
dc.date.accessioned2020-11-09T08:16:11Z
dc.date.available2020-11-09T08:16:11Z
dc.date.issued2018-04-16
dc.identifier.issn1758-5368 (Electronic) 1079-5014 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/12137
dc.description.abstractEnObjectives: Several epidemiological studies suggest declining trends in dementia over the last three decades with both decreasing age-specific prevalence and incidence. There is limited data on whether this delayed clinical onset is accompanied by a shorter postdiagnosis survival. Methods: A total of 5,205 participants from the Framingham Original and Offspring cohorts were studied. Four epochs were considered from 1977-1984 to 2004-2008. Gender and education adjusted 5-year mortality risks were estimated using delayed entry Cox models with the earliest epoch as reference category. Stratified analyses by sex, education, and age were undertaken. A nested case control study of 317 dementia cases and 317 controls matched on age, gender and epoch was initiated. Results: In the whole sample, 5-year mortality risk has decreased with time, it was 33% lower in the last epoch compared to the earliest. In the 317 persons who developed dementia, age at onset increased (1.5 years/epoch), and years alive with dementia decreased (1 year/epoch) over time. We observed however, a decreased adjusted relative mortality risk (by 18%) in persons with dementia in 1986-1991 compared to 1977-1983 and no significant change from then to the latest epoch. The nested case control study suggested in matched controls that 5-year mortality relative risk had increased by 60% in the last epoch compared to Epoch 1. Discussion: In the FHS, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.subject.enUMR
dc.title.enAre Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study
dc.title.alternativeJ Gerontol B Psychol Sci Soc Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/geronb/gby001en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29669105en_US
bordeaux.journalJournals of Gerontology Series B: Psychological Sciences and Social Sciencesen_US
bordeaux.pageS65-S72en_US
bordeaux.volume73en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issuesuppl_1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03164797
hal.version1
hal.date.transferred2021-03-10T10:00:55Z
hal.exporttrue
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