Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUPERRON, Marie-Gabrielle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SARGURUPREMRAJ, Muralidharan | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MAZOYER, Bernard | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SOUMARE, Aicha | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SCHILLING, Sabrina | |
| dc.contributor.author | AMOUYEL, Philippe | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHAUHAN, Ganesh | |
| dc.contributor.author | ZHU, Y. C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DEBETTE, Stephanie | |
| dc.date.accessioned | 2020-11-03T13:34:29Z | |
| dc.date.available | 2020-11-03T13:34:29Z | |
| dc.date.issued | 2018-02 | |
| dc.identifier.issn | 0039-2499 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/11602 | |
| dc.description.abstractEn | BACKGROUND AND PURPOSE: The genetic contribution to dilated perivascular space (dPVS) burden-an emerging MRI marker of cerebral small vessel disease-is unknown. We measured the heritability of dPVS burden and its shared heritability with other MRI markers of cerebral small vessel disease. METHODS: The study sample comprised 1597 participants from the population-based Three City (3C) Dijon Study, with brain MRI and genome-wide genotyping (mean age, 72.8+/-4.1 years; 61% women). dPVS burden and lacunar brain infarcts were rated on a semiquantitative scale, whereas an automated algorithm generated white matter hyperintensity volume (WMHV). We estimated dPVS burden heritability and shared heritability with WMHV and lacunar brain infarcts using the genome-wide complex trait analysis tool, on unrelated participants, adjusting for age, sex, intracranial volume, and principal components of population stratification. RESULTS: dPVS burden was significantly correlated with WMHV and lacunar brain infarcts, the strongest correlation being found between WMHV and dPVS in basal ganglia. Heritability estimates were h(2)=0.59+/-0.24 (P=0.007) for dPVS burden, h(2)=0.54+/-0.24 (P=0.010) for WMHV, and h(2)=0.48+/-0.81 (P=0.278) for lacunar brain infarcts. We found a nonsignificant trend toward shared heritability between dPVS and WMHV (rg=0.41+/-0.28; P=0.096), which seemed driven by dPVS in basal ganglia (rg=0.72+/-0.61; P=0.126) and not dPVS in white matter (rg=-0.10+/-0.36; P=0.393). A genetic risk score for WMHV based on published loci was associated with increased dPVS burden in basal ganglia (P=0.031). CONCLUSIONS: We provide evidence for important genetic contribution to dPVS burden in older community-dwelling people, some of which may be shared with WMHV. Differential heritability patterns for dPVS in white matter and basal ganglia suggest at least partly distinct underlying biological processes. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | VINTAGE | |
| dc.title.en | Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable | |
| dc.title.alternative | Stroke | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/strokeaha.117.019309 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29311265 | en_US |
| bordeaux.journal | Stroke | en_US |
| bordeaux.page | 282-287 | en_US |
| bordeaux.volume | 49 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.team | HEALTHY_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Stroke&rft.date=2018-02&rft.volume=49&rft.issue=2&rft.spage=282-287&rft.epage=282-287&rft.eissn=0039-2499&rft.issn=0039-2499&rft.au=DUPERRON,%20Marie-Gabrielle&TZOURIO,%20Christophe&SARGURUPREMRAJ,%20Muralidharan&MAZOYER,%20Bernard&SOUMARE,%20Aicha&rft.genre=article |
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