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Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma

dc.rights.licenseopenen_US
dc.contributor.authorDE ROOS, A. J.
dc.contributor.authorSPINELLI, J.
dc.contributor.authorBROWN, E. B.
dc.contributor.authorATANACKOVIC, D.
dc.contributor.authorBARIS, D.
dc.contributor.authorBERNSTEIN, L.
dc.contributor.authorBHATTI, P.
dc.contributor.authorCAMP, N. J.
dc.contributor.authorCHIU, B. C.
dc.contributor.authorCLAVEL, J.
dc.contributor.authorCOZEN, W.
dc.contributor.authorDE SANJOSE, S.
dc.contributor.authorDOSMAN, J. A.
dc.contributor.authorHOFMANN, J. N.
dc.contributor.authorMCLAUGHLIN, J. R.
dc.contributor.authorMILIGI, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorORSI, L.
dc.contributor.authorPURDUE, M. P.
dc.contributor.authorSCHINASI, L. H.
dc.contributor.authorTRICOT, G. J.
dc.contributor.authorWANG, S. S.
dc.contributor.authorZHANG, Y.
dc.contributor.authorBIRMANN, B. M.
dc.contributor.authorCOCCO, P.
dc.date.accessioned2020-11-02T15:31:03Z
dc.date.available2020-11-02T15:31:03Z
dc.date.issued2018-11
dc.identifier.issn1470-7926 (Electronic) 1351-0711 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11588
dc.description.abstractEnOBJECTIVES: To investigate the association between occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma (MM) in a large, consortium-based study. METHODS: We pooled data on 2854 cases and 10 743 controls from nine studies participating in the InterLymph consortium. Occupational exposures to benzene, toluene and xylene were assigned by a job-exposure matrix, coupled with 'correction' of exposure probability by self-reported or expert-assessed exposure from the individual studies. Cumulative intensity was calculated as the job-specific exposure intensity multiplied by job duration, summed across jobs. Associations were estimated using logistic regression, with inclusion of covariates for study matching factors and other potential confounders. We repeated our main analysis using random-effects meta-analysis to evaluate heterogeneity of effect. RESULTS: Benzene, toluene and xylene were each associated with MM. For the three solvents, the highest quartile of high-probability cumulative intensity exposure (vs unexposed) was associated with 42% to 63% increased risks of MM. Associations with toluene and xylene exposures were fairly consistent and robust to sensitivity analyses. The estimated effect for benzene was moderately heterogeneous between the studies. Each solvent's association with MM was stronger for exposure occurring within 20 years of diagnosis than with exposure lagged by more than 20 years. CONCLUSIONS: Our study adds important evidence for a role of aromatic hydrocarbon solvents in causation of MM. The difficulty in disentangling individual compounds in this group and a lack of data on potential carcinogenicity of toluene and xylene, in widespread current use, underscore a need for further epidemiological evaluation.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enPooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma
dc.title.alternativeOccup Environ Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/oemed-2018-105154en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30121582en_US
bordeaux.journalOccupational and Environmental Medicineen_US
bordeaux.page798-806en_US
bordeaux.volume75en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02986082
hal.version1
hal.date.transferred2020-11-02T15:31:10Z
hal.exporttrue
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