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Tidal Volume during Assisted Ventilation after Double-Lung Transplantation.

dc.rights.licenseopenen_US
dc.contributor.authorROZE, H.
dc.contributor.authorPIQUILLOUD, L.
dc.contributor.authorRICHARD, J. C. M.
dc.contributor.authorJOUGON, J.
dc.contributor.authorDROMER, C.
dc.contributor.authorMERCAT, A.
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorOUATTARA, A.
dc.contributor.authorBROCHARD, L.
dc.date.accessioned2020-10-27T14:54:58Z
dc.date.available2020-10-27T14:54:58Z
dc.date.issued2015-09
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11523
dc.description.abstractEnThe rate of lung transplants is increasing, and these patients frequently develop respiratory complications necessitating mechanical ventilation (1). When treating these patients, the risks of mechanical ventilation constitute an important concern, and clinicians aim to simultaneously protect the lung while avoiding ventilator-induced diaphragm dysfunction by maintaining spontaneous breathing. Targeting the ideal VT for each patient is challenging. According to the underlying lung disease of the recipient and his or her previous total lung capacity (TLC), the size of the transplanted lungs may differ from the theoretical TLC based on height. Actual TLC can vary considerably from one transplanted patient to the next and is poorly correlated with height (2). Furthermore, bipulmonary transplanted patients have denervated lungs without vagal afferent fibers. As a consequence, some feedback mechanisms necessary for control of breathing may be lacking, which can result in large VT, as shown in animals (3) and during exercise in lung-transplanted patients (4). Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation that delivers support in proportion to diaphragmatic electrical activity, the latter being a direct expression of neural inspiratory activity (5). Over a certain range of assist, the patient is able to fully control his or her VT, which is not the case with traditional modes of assist. We analyzed VT in patients ventilated with NAVA after bilateral lung transplantation. We compared these volumes with nontransplanted patients at a similar stage of difficult weaning, using the same approach to titrate NAVA. In addition, we examined the relationship between the patient’s VT under NAVA and their most recent TLC.
dc.language.isoFRen_US
dc.subjectArticle CLINIQUE
dc.title.enTidal Volume during Assisted Ventilation after Double-Lung Transplantation.
dc.title.alternativeAm J Respir Crit Care Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1164/rccm.201503-0592LEen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAmerican Journal of Respiratory and Critical Care Medicineen_US
bordeaux.page637–639en_US
bordeaux.volume192en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02980758
hal.version1
hal.date.transferred2020-10-27T14:55:03Z
hal.exporttrue
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