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Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4

dc.rights.licenseopenen_US
dc.contributor.authorMLIH, M.
dc.contributor.authorABDULRAHMAN, N.
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorGADEAU, Alain-Pierre
dc.contributor.authorMOHAMED, I. A.
dc.contributor.authorJABALLAH, M.
dc.contributor.authorMRAICHE, F.
dc.date.accessioned2020-10-27T14:51:06Z
dc.date.available2020-10-27T14:51:06Z
dc.date.issued2015-06
dc.identifier.issn1573-4919 (Electronic) 0300-8177 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11522
dc.description.abstractEnOsteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against hypertrophy and fibrosis mediated by Ang II. Recently, transgenic mice expressing the active form of the Na(+)/H(+) exchanger isoform 1 (NHE1) developed spontaneous hypertrophy in association with elevated levels of OPN. The mechanism by which active NHE1 induces OPN expression and contributes to the hypertrophic response remains unclear. To validate whether expression of the active form of NHE1 induces OPN, cardiomyocytes were stimulated with Ang II, a known inducer of both OPN and NHE1. Ang II induced hypertrophy and increased OPN protein expression (151.6 +/- 28.19 %, P \textless 0.01) and NHE1 activity in H9c2 cardiomyoblasts. Ang II-induced hypertrophy and OPN protein expression were regressed in the presence of an NHE1 inhibitor, EMD 87580, or a calcineurin inhibitor, FK506. In addition, our results indicated that activation of NHE1-induced NFAT3 translocation into the nucleus and a significant activation of the transcription factor Gata4 (NHE1: 149 +/- 28 % of control, P \textless 0.05). NHE1-induced activation of Gata4 was inhibited by FK506. In summary, our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3/Gata4 and OPN expression.
dc.language.isoENen_US
dc.subjectArticle RECHERCHE
dc.title.enNa(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11010-015-2380-8en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalMolecular and Cellular Biochemistryen_US
bordeaux.page211–20en_US
bordeaux.volume404en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.issue1-2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20and%20Cellular%20Biochemistry&rft.date=2015-06&rft.volume=404&rft.issue=1-2&rft.spage=211%E2%80%9320&rft.epage=211%E2%80%9320&rft.eissn=1573-4919%20(Electronic)%200300-8177%20(Linking)&rft.issn=1573-4919%20(Electronic)%200300-8177%20(Linking)&rft.au=MLIH,%20M.&ABDULRAHMAN,%20N.&GADEAU,%20Alain-Pierre&MOHAMED,%20I.%20A.&JABALLAH,%20M.&rft.genre=article


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