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Prevalence of toxoplasmosis and its association with dementia in older adults in central Africa: A result from the EPIDEMCA programme

dc.rights.licenseopenen_US
dc.contributor.authorBOUSCAREN, N.
dc.contributor.authorPILLERON, S.
dc.contributor.authorMBELESSO, P.
dc.contributor.authorNDAMBA-BANDZOUZI, B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorCLEMENT, J. P.
dc.contributor.authorPREUX, P. M.
dc.contributor.authorDARDE, M. L.
dc.contributor.authorGUERCHET, M.
dc.date.accessioned2020-10-26T13:56:31Z
dc.date.available2020-10-26T13:56:31Z
dc.date.issued2018-12
dc.identifier.issn1365-3156 (Electronic) 1360-2276 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11475
dc.description.abstractEnOBJECTIVE: We aimed at estimating the seroprevalence of Toxoplasma gondii infection in older adults living in Central Africa and investigating its association with dementia using data from the Epidemiology of Dementia in Central Africa (EPIDEMCA) programme. METHODS: A cross-sectional multicentre population-based study was carried out among participants aged 73 (+/-7) years on average, living in rural and urban areas of the Central African Republic and the Republic of Congo between November 2011 and December 2012. Blood samples were collected from each consenting participant. The detection of anti-T.gondii immunoglobulin G antibodies was performed in 2014 in France using a commercially available ELISA kit. Participants were interviewed using a standardized questionnaire including sociodemographic characteristics. DSM-IV criteria were required for a diagnosis of dementia. Multivariate binary logistic regression models were used to estimate the association between toxoplasmosis infection and dementia. RESULTS: Among 1,662 participants, the seroprevalence of toxoplasmosis was 63.0% (95% confidence interval (CI): 60.7-65.3) overall, 66.6% (95%CI: 63.4-69.8) in Central African Republic and 59.4% (95%CI: 56.1-62.7) in the Republic of Congo. In multivariate analyses, toxoplasmosis status was significantly associated with increasing age (p=0.006), Republic of Congo (p=0.002), urban area (p=0.001) and previous occupation (p=0.002). No associations between dementia and toxoplasmosis status or anti- T.gondii IgG titres were found. CONCLUSION: T.gondii infection was not associated with dementia among older adults in Central Africa. Our findings are consistent with previous studies and add to the knowledge on the relationship between T.gondii infection and neurological disorders. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.title.enPrevalence of toxoplasmosis and its association with dementia in older adults in central Africa: A result from the EPIDEMCA programme
dc.title.alternativeTrop Med Int Healthen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/tmi.13151en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30284355en_US
bordeaux.journalTropical medicine & international healthen_US
bordeaux.page1304-1313en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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