Afficher la notice abrégée

Recovery of Kidney Function in Children Treated with Maintenance Dialysis

dc.rights.licenseopenen_US
dc.contributor.authorBONTHUIS, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorBERARD, E.
dc.contributor.authorCRANSBERG, K.
dc.contributor.authorDUZOVA, A.
dc.contributor.authorGARNEATA, L.
dc.contributor.authorHERTHELIUS, M.
dc.contributor.authorLUNGU, A. C.
dc.contributor.authorJAHNUKAINEN, T.
dc.contributor.authorKALTENEGGER, L.
dc.contributor.authorARICETA, G.
dc.contributor.authorMAURER, E.
dc.contributor.authorPALSSON, R.
dc.contributor.authorSINHA, M. D.
dc.contributor.authorTESTA, S.
dc.contributor.authorGROOTHOFF, J. W.
dc.contributor.authorJAGER, K. J.
dc.date.accessioned2020-10-26T11:05:33Z
dc.date.available2020-10-26T11:05:33Z
dc.date.issued2018-10-08
dc.identifier.issn1555-9041en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11472
dc.description.abstractEnBACKGROUND AND OBJECTIVES: Data on recovery of kidney function in pediatric patients with presumed ESKD are scarce. We examined the occurrence of recovery of kidney function and its determinants in a large cohort of pediatric patients on maintenance dialysis in Europe. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data for 6574 patients from 36 European countries commencing dialysis at an age below 15 years, between 1990 and 2014 were extracted from the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry. Recovery of kidney function was defined as discontinuation of dialysis for at least 30 days. Time to recovery was studied using a cumulative incidence competing risk approach and adjusted Cox proportional hazard models. RESULTS: Two years after dialysis initiation, 130 patients (2%) experienced recovery of their kidney function after a median of 5.0 (interquartile range, 2.0-9.6) months on dialysis. Compared with patients with congenital anomalies of the kidney and urinary tract, recovery more often occurred in patients with vasculitis (11% at 2 years; adjusted hazard ratio [HR], 20.4; 95% confidence interval [95% CI], 9.7 to 42.8), ischemic kidney failure (12%; adjusted HR, 11.4; 95% CI, 5.6 to 23.1), and hemolytic uremic syndrome (13%; adjusted HR, 15.6; 95% CI, 8.9 to 27.3). Younger age and initiation on hemodialysis instead of peritoneal dialysis were also associated with recovery. For 42 patients (32%), recovery was transient as they returned to kidney replacement therapy after a median recovery period of 19.7 (interquartile range, 9.0-41.3) months. CONCLUSIONS: We demonstrate a recovery rate of 2% within 2 years after dialysis initiation in a large cohort of pediatric patients on maintenance dialysis. There is a clinically important chance of recovery in patients on dialysis with vasculitis, ischemic kidney failure, and hemolytic uremic syndrome, which should be considered when planning kidney transplantation in these children.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enRecovery of Kidney Function in Children Treated with Maintenance Dialysis
dc.title.alternativeClin J Am Soc Nephrolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2215/cjn.01500218en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30237216en_US
bordeaux.journalClinical journal of the American Society of Nephrologyen_US
bordeaux.page1510-1516en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02978235
hal.version1
hal.date.transferred2020-10-26T11:05:39Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20journal%20of%20the%20American%20Society%20of%20Nephrology&rft.date=2018-10-08&rft.volume=13&rft.issue=10&rft.spage=1510-1516&rft.epage=1510-1516&rft.eissn=1555-9041&rft.issn=1555-9041&rft.au=BONTHUIS,%20M.&HARAMBAT,%20Jerome&BERARD,%20E.&CRANSBERG,%20K.&DUZOVA,%20A.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée