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Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBILLA, Oumar
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHALOUNI, Mathieu
dc.contributor.authorSALMON, Dominique
dc.contributor.authorPOIZOT-MARTIN, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGILBERT, Camille
dc.contributor.authorKATLAMA, Christine
dc.contributor.authorNEAU, Didier
dc.contributor.authorCHAS, Julie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORLAT, Philippe
dc.contributor.authorLACOMBE, Karine
dc.contributor.authorNAQVI, Alissa
dc.contributor.authorBARANGE, Karl
dc.contributor.authorGERVAIS, Anne
dc.contributor.authorBOUCHAUD, Olivier
dc.contributor.authorROSENTHAL, Eric
dc.contributor.authorLASCOUX-COMBE, Caroline
dc.contributor.authorGARIPUY, Daniel
dc.contributor.authorALRIC, Laurent
dc.contributor.authorDOMINGUEZ, Stephanie
dc.contributor.authorVITTECOQ, Daniel
dc.contributor.authorGOUJARD, Cecile
dc.contributor.authorDUVIVIER, Claudine
dc.contributor.authorAUMAITRE, Hugues
dc.contributor.authorMIAILHES, Patrick
dc.contributor.authorZUCMAN, David
dc.contributor.authorSIMON, Anne
IDREF: 06114441X
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorRAFFI, Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorBANI-SADR, Firouze
dc.date.accessioned2020-10-20T13:13:00Z
dc.date.available2020-10-20T13:13:00Z
dc.date.issued2018-12-18
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11457
dc.description.abstractEnCompared to the general population, HIV-infected patients are at higher risk of developing non-AIDS-defining cancers. Chronic HCV infection has also been associated with a higher risk than that of the general population of developing cancers other than hepatocarcinoma. Evaluation of the impact of HCV-related factors on non-AIDS-defining and non HCV-liver (NANL) related cancers among HIV/HCV co-infected patients are scarce. The aim of this study was to identify the impact of HIV/HCV clinical characteristics on NANL related cancers in a large cohort of HIV/HCV-coinfected patients followed from 2005 to 2017. Cox proportional hazards models with delayed entry were used to estimate factors associated with NANL related cancer. Among 1391 patients followed for a median of 5 years, 60 patients developed NANL related cancers, yielding an incidence rate of 8.9 per 1000 person-years (95% CI, [6.6-11.1]). By final multivariable analysis, after adjustment for sex, tobacco or alcohol consumption, baseline CD4 cell count and HCV sustained viral response (SVR), age and a longer duration since HIV diagnosis were independently associated with a higher risk of NANL related cancer (aHR for each additional year 1.10, 95% CI 1.06-1.14, p<0.0001 and 1.06, 95% CI 1.01-1.11, p = 0.02, respectively). Duration of HCV infection, cirrhosis, HCV viral load, genotype and SVR were not associated with the occurrence of NANL related cancer. Among HIV/HCV-coinfected patients, age and the duration of HIV infection were the only characteristics found to be associated with the occurrence of NANL related cancer. In contrast, no association was observed with any HCV-related variables.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMORPH3Eus
dc.subject.enCIC1401
dc.title.enFactors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0208657en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30562358en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee0208657en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=PLoS%20ONE&amp;rft.date=2018-12-18&amp;rft.volume=13&amp;rft.issue=12&amp;rft.spage=e0208657&amp;rft.epage=e0208657&amp;rft.eissn=1932-6203&amp;rft.issn=1932-6203&amp;rft.au=BILLA,%20Oumar&amp;CHALOUNI,%20Mathieu&amp;SALMON,%20Dominique&amp;POIZOT-MARTIN,%20Isabelle&amp;GILBERT,%20Camille&amp;rft.genre=article


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