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Longitudinal trajectories of antidepressant use in pregnancy and the postnatal period

dc.rights.licenseopenen_US
dc.contributor.authorBANDOLI, G.
dc.contributor.authorKUO, G. M.
dc.contributor.authorSUGATHAN, R.
dc.contributor.authorCHAMBERS, C. D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROLLAND, Matthieu
dc.contributor.authorPALMSTEN, K.
dc.date.accessioned2020-10-19T10:03:03Z
dc.date.available2020-10-19T10:03:03Z
dc.date.issued2018-08
dc.identifier.issn1435-1102 (Electronic) 1434-1816 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11415
dc.description.abstractEnStudies of antidepressant safety in pregnancy typically do not address complex patterns of use throughout pregnancy. We performed longitudinal trajectory modeling to describe patterns of antidepressant use in the first 32 weeks of pregnancy, and test whether these trajectories are associated with a reduction in birth weight or gestational age at delivery. Our study included 166 pregnant women with deliveries between 2011 and 2015 who were prescribed an antidepressant between 91 days prior to last menstrual period and 32 weeks of gestation. From electronic medical records, we estimated average daily dose and cumulative dose per week for the first 32 weeks of gestation and for the first 13 weeks postnatal. We clustered women with similar utilization patterns using k-means longitudinal modeling and assessed the associations between trajectory group and birth weight and gestational age at delivery. We identified four cumulative dose trajectory groups and three average daily dose trajectory groups in each period. Relative to the lowest trajectory group, the highest trajectory group during pregnancy was associated with reduced birth weight in multivariable analysis (average daily highest trajectory vs. lowest trajectory beta - 314.1 g, 95% CI - 613.7, - 15.5) adjusted for depression severity score, maternal age, race, and pregnancy smoking. Trajectory groups were not associated with gestational age at delivery. The highest trajectory group of antidepressant use in pregnancy was associated with a modest reduction in birth weight but not with gestational age at delivery. Longitudinal trajectories allow for a dynamic visualization and quantification of medication use among pregnant women.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enLongitudinal trajectories of antidepressant use in pregnancy and the postnatal period
dc.title.alternativeArch Womens Ment Healthen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00737-018-0809-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29340802en_US
bordeaux.journalArchives of Women's Mental Healthen_US
bordeaux.page411-419en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03163283
hal.version1
hal.date.transferred2021-03-09T09:51:52Z
hal.exporttrue
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