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Specific features of amoxicillin-associated DRESS: a nationwide study

dc.rights.licenseopenen_US
dc.contributor.authorLARGEAU, B.
dc.contributor.authorAGIER, M. S.
dc.contributor.authorBEAU-SALINAS, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPARIENTE, Antoine
IDREF: 13395711X
dc.contributor.authorMARUANI, A.
dc.contributor.authorVIAL, T.
dc.contributor.authorJONVILLE-BERA, Annie-Pierre
dc.date.accessioned2021-10-08T12:13:51Z
dc.date.available2021-10-08T12:13:51Z
dc.date.issued2021-08-30
dc.identifier.issn0926-9959en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112704
dc.description.abstractEnBACKGROUND: Growing evidence indicates that amoxicillin induces herpesvirus replication in vitro. As these play a central pathophysiological role in Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), amoxicillin could present with specific DRESS features. OBJECTIVE: To characterize the onset patterns of amoxicillin-associated DRESS. METHODS: All cases of DRESS (Kardaun score≥4) involving amoxicillin and reported in the French Pharmacovigilance Database between January 1, 2004 and November 30, 2019 were included. Onset circumstances for these cases were categorized considering the onset delay from amoxicillin initiation, and the presence of concomitant medications with a compatible time to onset. RESULTS: A total of 146 probable cases or definite cases of DRESS were included. Three onset circumstances were identified: 1/ 'amoxicillin clear culprit' where amoxicillin was the sole suspect drug or when concomitant drugs of compatible time to onset were not reported to cause DRESS (n=62); 2/ 'amoxicillin possible culprit' in the presence of other potentially culprit drugs in addition to amoxicillin (n=44) and 3/ 'flare' where amoxicillin, used after DRESS onset, induced flare-up reactions (n=40). The median time to onset was 5 days (IQR 2-11) in 'clear culprit', and 18 days (IQR 7-26) in 'possible culprit' cases. In 'flare' cases the median latency between amoxicillin initiation and flare-up reactions was 3 days (IQR 2-5). CONCLUSIONS: Amoxicillin can induce DRESS with a specific early onset and exacerbate DRESS from another drug.
dc.language.isoENen_US
dc.title.enSpecific features of amoxicillin-associated DRESS: a nationwide study
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jdv.17631en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34459032en_US
bordeaux.journalJournal of the European Academy of Dermatology and Venereologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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