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Orotracheal administration of contrast agents: a new protocol for brain tumor targeting

hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBIANCHI, Andrea
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMONCELET, Damien
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorLUX, François
hal.structure.identifierNano-H SAS
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorPLISSONNEAU, Marie
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorRIZZITELLI, Silvia
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorRIBOT, Emeline
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTASSALI, Nawal
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUCHAUD, Véronique
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorTILLEMENT, Olivier
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorVOISIN, Pierre J.
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCRÉMILLIEUX, Yannick
dc.date.accessioned2021-10-07T16:30:30Z
dc.date.available2021-10-07T16:30:30Z
dc.date.issued2015
dc.identifier.issn0952-3480
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112695
dc.description.abstractEnThe development of new non-invasive diagnostic and therapeutic approaches is of paramount importance in order to improve the outcome of patients with glioblastoma (GBM). In this work we investigated a completely non-invasive pre-clinical protocol to effectively target and detect brain tumors through the orotracheal route, using ultra-small nanoparticles (USRPs) and MRI.A mouse model of GBM was developed. In vivo MRI acquisitions were performed before and after intravenous or orotracheal administration of the nanoparticles to identify and segment the tumor. The accumulation of the nanoparticles in neoplastic lesions was assessed ex vivo through fluorescence microscopy.Before the administration of contrast agents, MR images allowed the identification of the presence of abnormal brain tissue in 73% of animals. After orotracheal or intravenous administration of USRPs, in all the mice an excellent co-localization of the position of the tumor with MRI and histology was observed. The elimination time of the USRPs from the tumor after the orotracheal administration was approximately 70% longer compared with intravenous injection.MRI and USRPs were shown to be powerful imaging tools able to detect, quantify and longitudinally monitor the development of GBMs. The absence of ionizing radiation and high resolution of MRI, along with the complete non-invasiveness and good reproducibility of the proposed protocol, make this technique potentially translatable to humans. To our knowledge, this is the first time that the advantages of a needle-free orotracheal administration route have been demonstrated for the investigation of the pathomorphological changes due to GBMs.
dc.language.isoen
dc.publisherWiley
dc.subject.enlungs
dc.subject.encontrast agents
dc.subject.enMRI
dc.subject.englioblastoma
dc.subject.enorotracheal administration
dc.subject.enfluorescence imaging
dc.title.enOrotracheal administration of contrast agents: a new protocol for brain tumor targeting
dc.typeArticle de revue
dc.identifier.doi10.1002/nbm.3295
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
bordeaux.journalNMR in Biomedicine
bordeaux.page738–746
bordeaux.volume28
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01275131
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01275131v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NMR%20in%20Biomedicine&rft.date=2015&rft.volume=28&rft.issue=6&rft.spage=738%E2%80%93746&rft.epage=738%E2%80%93746&rft.eissn=0952-3480&rft.issn=0952-3480&rft.au=BIANCHI,%20Andrea&MONCELET,%20Damien&LUX,%20Fran%C3%A7ois&PLISSONNEAU,%20Marie&RIZZITELLI,%20Silvia&rft.genre=article


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