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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

hal.structure.identifierCentre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
dc.contributor.authorMERIENNE, Nicolas
hal.structure.identifierUNIROUEN - UFR Santé [UNIROUEN UFR Santé]
dc.contributor.authorMEUNIER, Cécile
hal.structure.identifierLaboratoire de neurosciences cognitives et adaptatives [LNCA]
dc.contributor.authorSCHNEIDER, Anne
hal.structure.identifierDépartement d'Informatique et de Recherche Opérationnelle [Montreal] [DIRO]
dc.contributor.authorSEGUIN, Jonathan
hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorNAIR, Satish
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorROCHER, Anne
hal.structure.identifierInstitut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC]
dc.contributor.authorLE GRAS, Stéphanie
hal.structure.identifierCentre de génétique et de physiologie moléculaire et cellulaire [CGPhiMC]
dc.contributor.authorKEIME, Celine
hal.structure.identifierUniversity of Auckland [Auckland]
dc.contributor.authorFAULL, Richard
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorPELLERIN, Luc
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorCHATTON, Jean-Yves
hal.structure.identifierBiologie et Pathologie du Neurone [Brain-C]
dc.contributor.authorNERI, Christian
hal.structure.identifierLaboratoire de neurosciences cognitives et adaptatives [LNCA]
dc.contributor.authorMÉRIENNE, Karine
hal.structure.identifierLaboratoire des Maladies Neurodégénératives - UMR 9199 [LMN]
dc.contributor.authorDÉGLON, Nicole
dc.date.accessioned2021-10-07T16:28:51Z
dc.date.available2021-10-07T16:28:51Z
dc.date.issued2019-02
dc.identifier.issn2211-1247
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112617
dc.description.abstractEnThe role of brain cell-type-specific functions and profiles in pathological and non-pathological contexts is still poorly defined. Such cell-type-specific gene expression profiles in solid, adult tissues would benefit from approaches that avoid cellular stress during isolation. Here, we developed such an approach and identified highly selective transcriptomic signatures in adult mouse striatal direct and indirect spiny projection neurons, astrocytes, and microglia. Integrating transcriptomic and epigenetic data, we obtained a comprehensive model for cell-type-specific regulation of gene expression in the mouse striatum. A cross-analysis with transcriptomic and epigenomic data generated from mouse and human Huntington’s disease (HD) brains shows that opposite epigenetic mechanisms govern the transcriptional regulation of striatal neurons and glial cells and may contribute to pathogenic and compensatory mechanisms. Overall, these data validate this less stressful method for the investigation of cellular specificity in the adult mouse brain and demonstrate the potential of integrative studies using multiple databases.
dc.language.isoen
dc.publisherElsevier Inc
dc.title.enCell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures
dc.typeArticle de revue
dc.identifier.doi10.1016/j.celrep.2019.02.003
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalCell Reports
bordeaux.page2477-2493.e9
bordeaux.volume26
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02472468
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02472468v1
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