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Neuroprotective Effect of Maternal Resveratrol Supplementation in a Rat Model of Neonatal Hypoxia-Ischemia

hal.structure.identifierDépartement de Physiologie
dc.contributor.authorDUMONT, Ursule
dc.contributor.authorSANCHEZ, Stephane
hal.structure.identifierDépartement de Physiologie
dc.contributor.authorREPOND, Cendrine
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBEAUVIEUX, Marie Christine
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCHATEIL, Jean-Francois
hal.structure.identifierDépartement de Physiologie
hal.structure.identifierIschémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] [ IRTOMIT [Poitiers]]
dc.contributor.authorPELLERIN, Luc
dc.contributor.authorBOUZIER-SORE, Anne-Karine
dc.contributor.authorROUMES, Hélène
dc.date.accessioned2021-10-07T16:28:09Z
dc.date.available2021-10-07T16:28:09Z
dc.date.issued2021-01-15
dc.identifier.issn1662-4548
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112585
dc.description.abstractEnNeonatal hypoxia-ischemia (nHI) is a major cause of death or subsequent disabilities in infants. Hypoxia-ischemia causes brain lesions, which are induced by a strong reduction in oxygen and nutrient supply. Hypothermia is the only validated beneficial intervention, but not all newborns respond to it and today no pharmacological treatment exists. Among possible therapeutic agents to test, trans-resveratrol is an interesting candidate as it has been reported to exhibit neuroprotective effects in some neurodegenerative diseases. This experimental study aimed to investigate a possible neuroprotection by resveratrol in rat nHI, when administered to the pregnant rat female, at a nutritional dose. Several groups of pregnant female rats were studied in which resveratrol was added to drinking water either during the last week of pregnancy, the first week of lactation, or both. Then, 7-day old pups underwent a hypoxic-ischemic event. Pups were followed longitudinally, using both MRI and behavioral testing. Finally, a last group was studied in which breastfeeding females were supplemented 1 week with resveratrol just after the hypoxic-ischemic event of the pups (to test the curative rather than the preventive effect). To decipher the molecular mechanisms of this neuroprotection, RT-qPCR and Western blots were also performed on pup brain samples. Data clearly indicated that when pregnant and/or breastfeeding females were supplemented with resveratrol, hypoxic-ischemic offspring brain lesions were significantly reduced. Moreover, maternal resveratrol supplementation allowed to reverse sensorimotor and cognitive deficits caused by the insult. The best recoveries were observed when resveratrol was administered during both gestation and lactation (2 weeks before the hypoxic-ischemic event in pups). Furthermore, neuroprotection was also observed in the curative group, but only at the latest stages examined. Our hypothesis is that resveratrol, in addition to the well-known neuroprotective benefits via the sirtuin's pathway (antioxidant properties, inhibition of apoptosis), has an impact on brain metabolism, and more specifically on the astrocyte-neuron lactate shuttle (ANLS) as suggested by RT-qPCR and Western blot data, that contributes to the neuroprotective effects.
dc.language.isoen
dc.publisherFrontiers
dc.subject.enMRI
dc.subject.enbrain metabolism
dc.subject.enneonatal hypoxia-ischemia
dc.subject.enpolyphenol
dc.subject.enresveratrol
dc.title.enNeuroprotective Effect of Maternal Resveratrol Supplementation in a Rat Model of Neonatal Hypoxia-Ischemia
dc.typeArticle de revue
dc.identifier.doi10.3389/fnins.2020.616824
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
bordeaux.journalFrontiers in Neuroscience
bordeaux.volume14
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03129125
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03129125v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Neuroscience&rft.date=2021-01-15&rft.volume=14&rft.eissn=1662-4548&rft.issn=1662-4548&rft.au=DUMONT,%20Ursule&SANCHEZ,%20Stephane&REPOND,%20Cendrine&BEAUVIEUX,%20Marie%20Christine&CHATEIL,%20Jean-Francois&rft.genre=article


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